Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/2456
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dc.contributor.authorSexton, Claire Een_UK
dc.contributor.authorMackay, Clare Een_UK
dc.contributor.authorLonie, Jane Aen_UK
dc.contributor.authorBastin, Mark Een_UK
dc.contributor.authorTerriere, Emmaen_UK
dc.contributor.authorO'Carroll, Ronanen_UK
dc.contributor.authorEbmeier, Klaus Pen_UK
dc.date.accessioned2016-11-30T23:33:20Z-
dc.date.available2016-11-30T23:33:20Zen_UK
dc.date.issued2010-10-30en_UK
dc.identifier.urihttp://hdl.handle.net/1893/2456-
dc.description.abstractEpisodic memory is a core feature of Alzheimer's disease (AD) and mild cognitive impairment (MCI). Impaired episodic memory in AD results from the dysfunction of an integrated network and involves both gray and white matter pathologies. We explored the neural correlates of episodic memory in AD, MCI and healthy aging by correlating a measure of episodic memory with hippocampal volume and fractional anisotropy (FA) and mean diffusivity (MD) of the cingulum and fornix. Episodic memory was associated with hippocampal volume and MD of the cingulum and fornix. In contrast, there were fewer significant associations between episodic memory and FA. These findings support a relationship between episodic memory and hippocampal circuitry, and suggest that MD is a more sensitive marker of decreased white matter integrity in the study of AD and MCI than FA. Furthermore, MD was significantly associated with hippocampal volume, indicating that white matter pathology is not completely independent of gray matter pathology. However, the pattern of diffusivity differences in AD and MCI implies a more complex pathology than simply Wallerian degeneration.en_UK
dc.language.isoenen_UK
dc.publisherElsevieren_UK
dc.relationSexton CE, Mackay CE, Lonie JA, Bastin ME, Terriere E, O'Carroll R & Ebmeier KP (2010) MRI correlates of episodic memory in Alzheimer's disease, mild cognitive impairment, and healthy aging, Psychiatry Research: Neuroimaging, 184 (1), pp. 57-62. https://doi.org/10.1016/j.pscychresns.2010.07.005.en_UK
dc.rightsThe publisher does not allow this work to be made publicly available in this Repository. Please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author; you can only request a copy if you wish to use this work for your own research or private study.en_UK
dc.subjectDementiaen_UK
dc.subjectNeuropsychologyen_UK
dc.subjectVoxel based morphometryen_UK
dc.subjectDiffusion tensor imagingen_UK
dc.titleMRI correlates of episodic memory in Alzheimer's disease, mild cognitive impairment, and healthy agingen_UK
dc.typeJournal Articleen_UK
dc.rights.embargodate2999-12-30en_UK
dc.rights.embargoreason[O'Carroll21.pdf] : The publisher does not allow this work to be made publicly available in this Repository therefore there is an embargo on the full text of the work.en_UK
dc.identifier.doi10.1016/j.pscychresns.2010.07.005en_UK
dc.citation.jtitlePsychiatry Research: Neuroimagingen_UK
dc.citation.issn0925-4927en_UK
dc.citation.volume184en_UK
dc.citation.issue1en_UK
dc.citation.spage57en_UK
dc.citation.epage62en_UK
dc.citation.publicationstatusPublisheden_UK
dc.citation.peerreviewedRefereeden_UK
dc.type.statusVoR - Version of Recorden_UK
dc.author.emailreo1@stir.ac.uken_UK
dc.contributor.affiliationUniversity of Oxforden_UK
dc.contributor.affiliationUniversity of Oxforden_UK
dc.contributor.affiliationUniversity of Edinburghen_UK
dc.contributor.affiliationUniversity of Edinburghen_UK
dc.contributor.affiliationUniversity of Edinburghen_UK
dc.contributor.affiliationPsychologyen_UK
dc.contributor.affiliationUniversity of Edinburghen_UK
dc.identifier.isi000283406100008en_UK
dc.identifier.scopusid2-s2.0-77956967451en_UK
dc.identifier.wtid811436en_UK
dc.contributor.orcid0000-0002-5130-291Xen_UK
dc.date.firstcompliantdepositdate2010-10-11en_UK
Appears in Collections:Psychology Journal Articles

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