Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/24461
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dc.contributor.authorMartin-Pozuelo, Gala-
dc.contributor.authorGonzalez-Barrio, Rocio-
dc.contributor.authorBarbera, Gonzalo-
dc.contributor.authorAlbalat, Amaya-
dc.contributor.authorGarcia-Alonso, Javier-
dc.contributor.authorMullen, William-
dc.contributor.authorMischak, Harald-
dc.contributor.authorPeriago, Maria Jesus-
dc.date.accessioned2017-06-14T23:51:23Z-
dc.date.available2017-06-14T23:51:23Z-
dc.date.issued2016-10-
dc.identifier.other1789-
dc.identifier.urihttp://hdl.handle.net/1893/24461-
dc.description.abstractNon-alcoholic fatty liver disease (NAFLD) is the most common liver disorder in Western countries, with a high prevalence, and has been shown to increase the risk of type 2 diabetes, cardiovascular disease (CVD), etc. Tomato products contain several natural antioxidants, including lycopene—which has displayed a preventive effect on the development of steatosis and CVD. Accordingly, the aim of the present work was to evaluate the effect of tomato juice consumption on the urinary peptide profile in rats with NAFLD induced by an atherogenic diet and to identify potential peptide biomarkers for diagnosis. Urine samples, collected weekly for four weeks, were analyzed by capillary electrophoresis (CE) coupled to a mass spectrometer (MS). A partial least squares-discriminant analysis (PLS-DA) was carried out to explore the association between differential peptides and treatments. Among the 888 peptides initially identified, a total of 55 were obtained as potential biomarkers. Rats with steatosis after tomato juice intake showed a profile intermediate between that of healthy rats and that of rats with induced hepatic steatosis. Accordingly, tomato products could be considered as a dietary strategy for the impairment of NAFLD, although further research should be carried out to develop a specific biomarkers panel for NAFLD.en_UK
dc.language.isoen-
dc.publisherMDPI-
dc.relationMartin-Pozuelo G, Gonzalez-Barrio R, Barbera G, Albalat A, Garcia-Alonso J, Mullen W, Mischak H & Periago MJ (2016) Tomato Juice Consumption Modifies the Urinary Peptide Profile in Sprague-Dawley Rats with Induced Hepatic Steatosis, International Journal of Molecular Sciences, 17 (11), Art. No.: 1789.-
dc.rightsThis is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0). Martín-Pozuelo, G.; González-Barrio, R.; Barberá, G.G.; Albalat, A.; García-Alonso, J.; Mullen, W.; Mischak, H.; Periago, M.J. Tomato Juice Consumption Modifies the Urinary Peptide Profile in Sprague-Dawley Rats with Induced Hepatic Steatosis. Int. J. Mol. Sci. 2016, 17, 1789.-
dc.subjectnon-alcoholic fatty liver disease (NAFLD)en_UK
dc.subjecttomatoen_UK
dc.subjectbiomarkersen_UK
dc.subjectpeptidomeen_UK
dc.subjectproteomeen_UK
dc.subjecturineen_UK
dc.subjectcapillary electrophoresis coupled to a mass spectrometer (CE-MS)en_UK
dc.subjectdiagnosisen_UK
dc.subjectliveren_UK
dc.titleTomato Juice Consumption Modifies the Urinary Peptide Profile in Sprague-Dawley Rats with Induced Hepatic Steatosisen_UK
dc.typeJournal Articleen_UK
dc.identifier.doihttp://dx.doi.org/10.3390/ijms17111789-
dc.citation.jtitleInternational Journal of Molecular Sciences-
dc.citation.issn1661-6596-
dc.citation.volume17-
dc.citation.issue11-
dc.citation.publicationstatusPublished-
dc.citation.peerreviewedRefereed-
dc.type.statusPublisher version (final published refereed version)-
dc.author.emailamaya.albalat@stir.ac.uk-
dc.citation.date26/10/2016-
dc.contributor.affiliationUniversity of Murcia-
dc.contributor.affiliationUniversity of Murcia-
dc.contributor.affiliationSpanish National Research Council (CSIC)-
dc.contributor.affiliationComplex Systems-
dc.contributor.affiliationUniversity of Murcia-
dc.contributor.affiliationUniversity of Glasgow-
dc.contributor.affiliationUniversity of Glasgow-
dc.contributor.affiliationUniversity of Murcia-
dc.identifier.isi000388809600023-
Appears in Collections:Aquaculture Journal Articles

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