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dc.contributor.authorMetochis, Christoforosen_UK
dc.contributor.authorSpanos, Iliasen_UK
dc.contributor.authorAuchinachie, Niallen_UK
dc.contributor.authorCrampton, Viven_UK
dc.contributor.authorAdams, Alexandraen_UK
dc.contributor.authorThompson, Kim Den_UK
dc.description.abstractJuvenile salmon, with an initial weight of 9g, were fed three experimental diets, formulated to replace 35 (SPC35), 58 (SPC58) and 80 (SPC80) of high quality fishmeal (FM) with soy protein concentrate (SPC) in quadruplicate tanks. Higher dietary SPC inclusion was combined with increased supplementation of methionine, lysine, threonine and phosphorus. The experiment was carried out for 177 days. On day 92 salmon in each tank were bulk weighed. Post weighing eighty salmon from each tank were redistributed in two sets of 12 tanks. Salmon from the first set of tanks were vaccinated, while the second group was injected with phosphate buffer saline (PBS). Salmon were sampled on day 92 (pre-vaccination), day 94 (2 days post vaccination [dpv]/PBS injection [dpPBSinj]) and day 154 (62 dpv/dpPBSinj) of the trial for the assessment of their immune responses, prior to the performance of salmon bulk weights for each tank. On day 154, fish from each tank were again bulk weighed and then seventeen salmon per tank were redistributed in two sets of twelve tanks and intra-peritoneally infected with Aeromonas salmonicida. At Day 154, SPC80 demonstrated lower performance (weight gain, specific growth rate and thermal growth coefficient and feed conversion ratio) compared to SPC35 salmon. Reduced classical and total complement activities for salmon fed diets with over 58% of protein from SPC, were demonstrated prior to vaccination. Reduced alternative complement activity was detected for both SPC58 and SPC80 salmon at 2 dpv and for the SPC80 group at 62 dpv. Total and classical complement activities demonstrated no differences among the dietary groups after vaccination. Numerical increases in classical complement activity were apparent upon increased dietary SPC levels. Increased phagocytic activity (% phagocytosis and phagocytic index) was exhibited for the SPC58 group compared to SPC35 salmon at 62 dpPBSinj. No differences in serum lysozyme activity, total IgM, specific antibodies, protein, glucose and HKM respiratory burst were detected among the dietary groups at any timepoint or state. Mortalities as a result of the experimental infection only occurred in PBS-injected fish. No differences in mortality levels were demonstrated among the dietary groups. SPC58 diet supported both good growth and health in juvenile Atlantic salmon while SPC80 diet did not compromise salmon’ immunity or resistance to intraperitoneally inflicted furunculosis.en_UK
dc.relationMetochis C, Spanos I, Auchinachie N, Crampton V, Adams A & Thompson KD (2016) The effects of increasing dietary levels of soy protein concentrate (SPC) on the immune responses and disease resistance (furunculosis) of vaccinated and non-vaccinated Atlantic salmon (Salmo salar L.) parr. Fish and Shellfish Immunology, 59, pp. 83-94.
dc.rightsThis item has been embargoed for a period. During the embargo please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study. Accepted refereed manuscript of: Metochis C, Spanos I, Auchinachie N, Crampton V, Adams A & Thompson KD (2016) The effects of increasing dietary levels of soy protein concentrate (SPC) on the immune responses and disease resistance (furunculosis) of vaccinated and non-vaccinated Atlantic salmon (Salmo salar L.) parr, Fish and Shellfish Immunology, 59, pp. 83-94. DOI: 10.1016/j.fsi.2016.10.016 © 2016, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
dc.subjectAtlantic salmonen_UK
dc.subjectSoy protein concentrateen_UK
dc.subjectImmune functionen_UK
dc.titleThe effects of increasing dietary levels of soy protein concentrate (SPC) on the immune responses and disease resistance (furunculosis) of vaccinated and non-vaccinated Atlantic salmon (Salmo salar L.) parren_UK
dc.typeJournal Articleen_UK
dc.rights.embargoreason[MS FS Immulogy (2).pdf] Publisher requires embargo of 12 months after formal publication.en_UK
dc.citation.jtitleFish and Shellfish Immunologyen_UK
dc.type.statusAM - Accepted Manuscripten_UK
dc.contributor.affiliationInstitute of Aquacultureen_UK
dc.contributor.affiliationScottish Salmon Companyen_UK
dc.contributor.affiliationFAI Aquaculture Ltden_UK
dc.contributor.affiliationEWOS Innovationen_UK
dc.contributor.affiliationInstitute of Aquacultureen_UK
dc.contributor.affiliationThe Moredun Research Instituteen_UK
rioxxterms.apcnot requireden_UK
rioxxterms.typeJournal Article/Reviewen_UK
local.rioxx.authorMetochis, Christoforos|0000-0002-3299-0630en_UK
local.rioxx.authorSpanos, Ilias|en_UK
local.rioxx.authorAuchinachie, Niall|en_UK
local.rioxx.authorCrampton, Viv|en_UK
local.rioxx.authorAdams, Alexandra|en_UK
local.rioxx.authorThompson, Kim D|en_UK
local.rioxx.projectInternal Project|University of Stirling|
local.rioxx.filenameMS FS Immulogy (2).pdfen_UK
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