Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/24382
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dc.contributor.authorRey, Soniaen_UK
dc.contributor.authorMoiche Vega, Ana Visilaen_UK
dc.contributor.authorBoltana, Sebastianen_UK
dc.contributor.authorTeles, Marianaen_UK
dc.contributor.authorMacKenzie, Simonen_UK
dc.date.accessioned2017-01-12T22:56:25Z-
dc.date.available2017-01-12T22:56:25Z-
dc.date.issued2017-02en_UK
dc.identifier.urihttp://hdl.handle.net/1893/24382-
dc.description.abstractBehavioural fever has been reported in different species of mobile ectotherms including the zebrafish,Danio rerio, in response to exogenous pyrogens. In this study we report, to our knowledge for the first time, upon the ontogenic onset of behavioural fever in zebrafish (Danio rerio) larvae. For this, zebrafish larvae (from first feeding to juveniles) were placed in a continuous thermal gradient providing the opportunity to select their preferred temperature. The novel thermal preference aquarium was based upon a continuous vertical column system and allows for non-invasive observation of larvae vertical distribution under isothermal (TRat 28°C) and thermal gradient conditions (TCH: 28-32°C). Larval thermal preference was assessed under both conditions with or without an immersion challenge, in order to detect the onset of the behavioural fever response. Our results defined the onset of the dsRNA induced behavioural fever at 18–20 days post fertilization (dpf). Significant differences were observed in dsRNA challenged larvae, which prefer higher temperatures (1–4°C increase) throughout the experimental period as compared to non-challenged larvae. In parallel we measured the abundance of antiviral transcripts;viperin, gig2, irf7, trim25andMxbmRNAs in dsRNA challenged larvae under both thermal regimes: TRand TCh. Significant increases in the abundance of all measured transcripts were recorded under thermal choice conditions signifying that thermo-coupling and the resultant enhancement of the immune response to dsRNA challenge occurs from 18dpf onwards in the zebrafish. The results are of importance as they identify a key developmental stage where the neuro-immune interface matures in the zebrafish likely providing increased resistance to viral infection.en_UK
dc.language.isoenen_UK
dc.publisherElsevieren_UK
dc.relationRey S, Moiche Vega AV, Boltana S, Teles M & MacKenzie S (2017) Behavioural fever in zebrafish larvae. Developmental and Comparative Immunology, 67, pp. 287-292. https://doi.org/10.1016/j.dci.2016.09.008en_UK
dc.rightsThis item has been embargoed for a period. During the embargo please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study. Accepted refereed manuscript of: Rey S, Moiche Vega AV, Boltana S, Teles M & MacKenzie S (2017) Behavioural fever in zebrafish larvae, Developmental and Comparative Immunology, 67, pp. 287-292. DOI: 10.1016/j.dci.2016.09.008 © 2016, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/en_UK
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en_UK
dc.subjectZebrafish larvaeen_UK
dc.subjectThermo-preferenceen_UK
dc.subjectBehavioural feveren_UK
dc.subjectAntiviral responseen_UK
dc.subjectdsRNA challengeen_UK
dc.subjectLarval developmenten_UK
dc.subjectTemperature choiceen_UK
dc.titleBehavioural fever in zebrafish larvaeen_UK
dc.typeJournal Articleen_UK
dc.rights.embargodate2017-09-24en_UK
dc.rights.embargoreason[Behavioural_fever_in_larvae.pdf] Publisher requires embargo of 12 months after formal publication.en_UK
dc.identifier.doi10.1016/j.dci.2016.09.008en_UK
dc.identifier.pmid27670815en_UK
dc.citation.jtitleDevelopmental and Comparative Immunologyen_UK
dc.citation.issn0145-305Xen_UK
dc.citation.volume67en_UK
dc.citation.spage287en_UK
dc.citation.epage292en_UK
dc.citation.publicationstatusPublisheden_UK
dc.citation.peerreviewedRefereeden_UK
dc.type.statusAM - Accepted Manuscripten_UK
dc.author.emailsonia.reyplanellas@stir.ac.uken_UK
dc.citation.date23/09/2016en_UK
dc.contributor.affiliationInstitute of Aquacultureen_UK
dc.contributor.affiliationInstitute of Aquacultureen_UK
dc.contributor.affiliationInstitute of Aquacultureen_UK
dc.contributor.affiliationUniversitat Autonoma de Barcelonaen_UK
dc.contributor.affiliationInstitute of Aquacultureen_UK
dc.identifier.isiWOS:000390071200028en_UK
dc.identifier.scopusid2-s2.0-85000500193en_UK
dc.identifier.wtid547325en_UK
dc.contributor.orcid0000-0002-3406-3291en_UK
dc.contributor.orcid0000-0003-1845-6826en_UK
dc.date.accepted2016-09-15en_UK
dcterms.dateAccepted2016-09-15en_UK
dc.date.filedepositdate2016-10-07en_UK
rioxxterms.apcnot requireden_UK
rioxxterms.typeJournal Article/Reviewen_UK
rioxxterms.versionAMen_UK
local.rioxx.authorRey, Sonia|0000-0002-3406-3291en_UK
local.rioxx.authorMoiche Vega, Ana Visila|en_UK
local.rioxx.authorBoltana, Sebastian|en_UK
local.rioxx.authorTeles, Mariana|en_UK
local.rioxx.authorMacKenzie, Simon|0000-0003-1845-6826en_UK
local.rioxx.projectInternal Project|University of Stirling|https://isni.org/isni/0000000122484331en_UK
local.rioxx.freetoreaddate2017-09-24en_UK
local.rioxx.licencehttp://www.rioxx.net/licenses/under-embargo-all-rights-reserved||2017-09-23en_UK
local.rioxx.licencehttp://creativecommons.org/licenses/by-nc-nd/4.0/|2017-09-24|en_UK
local.rioxx.filenameBehavioural_fever_in_larvae.pdfen_UK
local.rioxx.filecount1en_UK
local.rioxx.source0145-305Xen_UK
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