|Appears in Collections:||Faculty of Health Sciences and Sport Journal Articles|
|Peer Review Status:||Refereed|
|Title:||Tour de France Champions born or made: where do we take the genetics of performance?|
|Author(s):||Moran, Colin Neil|
elite athlete cohorts
|Citation:||Moran CN & Pitsiladis Y (2017) Tour de France Champions born or made: where do we take the genetics of performance?, Journal of Sports Sciences, 35 (14), pp. 1411-1419.|
|Abstract:||Cyclists in the Tour de France are endurance specialists. Twin and family studies have shown that approximately 50% of the variance in a number of performance-related phenotypes (whether measured at baseline, i.e., natural talent, or in response to training) including those important to cycling can be explained by genetic variation. Research into the specific genetic variants that are responsible has identified over 200 genes containing common genetic variants involved in the genetic predisposition to physical performance. However, typically these explain only a small portion of the variance, perhaps 1–2% and collectively they rarely explain anything approaching the 50% of the variance identified in the twin and family studies. Thus, there is a gap in our understanding of the relationship between heritability and performance. This gap may be bridged by investigation of rare variants or epigenetic variation or by altering study designs through increased collaborations to pool existing cohorts together. Initial findings from such efforts show promising results. This mini-review will touch on the genetics and epigenetics of sporting performance, how they relate to cyclists in the Tour de France and where best future efforts may be directed as well as discuss some preliminary research findings.|
|Rights:||This item has been embargoed for a period. During the embargo please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study. This is an Accepted Manuscript of an article published by Taylor & Francis Group in Journal of Sports Sciences on 06 Aug 2016, available online: http://www.tandfonline.com/10.1080/02640414.2016.1215494|
|Moran and Pitsiladis 2016 vAccepted version for repositories.pdf||669.81 kB||Adobe PDF||View/Open|
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