Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/24285
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dc.contributor.authorMoran, Colin Neilen_UK
dc.contributor.authorPitsiladis, Yannisen_UK
dc.date.accessioned2017-05-30T03:14:46Z-
dc.date.available2017-05-30T03:14:46Z-
dc.date.issued2017en_UK
dc.identifier.urihttp://hdl.handle.net/1893/24285-
dc.description.abstractCyclists in the Tour de France are endurance specialists. Twin and family studies have shown that approximately 50% of the variance in a number of performance-related phenotypes (whether measured at baseline, i.e., natural talent, or in response to training) including those important to cycling can be explained by genetic variation. Research into the specific genetic variants that are responsible has identified over 200 genes containing common genetic variants involved in the genetic predisposition to physical performance. However, typically these explain only a small portion of the variance, perhaps 1–2% and collectively they rarely explain anything approaching the 50% of the variance identified in the twin and family studies. Thus, there is a gap in our understanding of the relationship between heritability and performance. This gap may be bridged by investigation of rare variants or epigenetic variation or by altering study designs through increased collaborations to pool existing cohorts together. Initial findings from such efforts show promising results. This mini-review will touch on the genetics and epigenetics of sporting performance, how they relate to cyclists in the Tour de France and where best future efforts may be directed as well as discuss some preliminary research findings.en_UK
dc.language.isoenen_UK
dc.publisherTaylor and Francisen_UK
dc.relationMoran CN & Pitsiladis Y (2017) Tour de France Champions born or made: where do we take the genetics of performance?. Journal of Sports Sciences, 35 (14), pp. 1411-1419. https://doi.org/10.1080/02640414.2016.1215494en_UK
dc.rightsThis item has been embargoed for a period. During the embargo please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study. This is an Accepted Manuscript of an article published by Taylor & Francis Group in Journal of Sports Sciences on 06 Aug 2016, available online: http://www.tandfonline.com/10.1080/02640414.2016.1215494en_UK
dc.subjectGeneticsen_UK
dc.subjectepigeneticsen_UK
dc.subjectcyclistsen_UK
dc.subjectelite athlete cohortsen_UK
dc.subjectPowerGeneen_UK
dc.subjectGAMESen_UK
dc.subjectAthlomeen_UK
dc.titleTour de France Champions born or made: where do we take the genetics of performance?en_UK
dc.typeJournal Articleen_UK
dc.rights.embargoreason[Moran and Pitsiladis 2016 vAccepted version for repositories.pdf] Publisher requires embargo of 18 months after online publication.en_UK
dc.identifier.doi10.1080/02640414.2016.1215494en_UK
dc.identifier.pmid27498724en_UK
dc.citation.jtitleJournal of Sports Sciencesen_UK
dc.citation.issn1466-447Xen_UK
dc.citation.issn0264-0414en_UK
dc.citation.volume35en_UK
dc.citation.issue14en_UK
dc.citation.spage1411en_UK
dc.citation.epage1419en_UK
dc.citation.publicationstatusPublisheden_UK
dc.citation.peerreviewedRefereeden_UK
dc.type.statusAM - Accepted Manuscripten_UK
dc.author.emailcolin.moran@stir.ac.uken_UK
dc.citation.date06/08/2016en_UK
dc.contributor.affiliationSporten_UK
dc.contributor.affiliationUniversity of Brightonen_UK
dc.identifier.isiWOS:000400067900014en_UK
dc.identifier.scopusid2-s2.0-84982863267en_UK
dc.identifier.wtid549427en_UK
dc.contributor.orcid0000-0001-6226-8131en_UK
dc.date.accepted2016-07-15en_UK
dc.date.filedepositdate2016-09-22en_UK
Appears in Collections:Faculty of Health Sciences and Sport Journal Articles

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