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dc.contributor.authorSeetho, Ian Wen_UK
dc.contributor.authorRamirez-Torres, Adelaen_UK
dc.contributor.authorAlbalat, Amayaen_UK
dc.contributor.authorMullen, Williamen_UK
dc.contributor.authorMischak, Haralden_UK
dc.contributor.authorParker, Robert Jen_UK
dc.contributor.authorCraig, Sonyaen_UK
dc.contributor.authorDuffy, Nicken_UK
dc.contributor.authorHardy, Kevin Jen_UK
dc.contributor.authorBurniston, Jatin Gen_UK
dc.contributor.authorWilding, John P Hen_UK
dc.description.abstractIntroduction:  Obstructive sleep apnoea (OSA) is common in obesity and is associated with cardiovascular and metabolic complications. Continuous positive airway pressure (CPAP) in OSA may lead to physiological changes reflected in the urinary proteome. The aim of this study was to characterise the urinary proteome in severely obese adult subjects with OSA who were receiving CPAP compared with severely obese subjects without OSA.  Methods:  Severely obese subjects with and without OSA were recruited. Subjects with OSA were receiving CPAP. Body composition and blood pressure measurements were recorded. Urinary samples were analysed by Capillary Electrophoresis-Mass Spectrometry (CE-MS).  Results:  Twenty-seven subjects with OSA-on-CPAP (age 49 + 7years, BMI 43 + 7kg/m2) and 25 controls without OSA (age 52+9years, BMI 39+4kg/m2) were studied. Age and BMI were not significantly different between groups. Mean CPAP use for OSA patients was 14.5 + 1.0 months. Metabolic syndrome was present in 14(52%) of those with OSA compared with 6(24%) of controls (p=0.039). A urinary proteome comprising 15 peptides was identified showing differential expression between the groups (p<0.01). Although correction for multiple testing did not reach significance, sequences were determined for 8 peptides demonstrating origins from collagens, fibrinogen beta chain and T-cadherin that may be associated with underlying cardiovascular disease mechanisms in OSA.  Conclusions:  The urinary proteome is compared in OSA with CPAP and without OSA in severe obesity. The effects of CPAP on OSA may lead to changes in the urinary peptides but further research work is needed to investigate the potential role for urinary proteomics in characteris­ing urinary peptide profiles in OSA. © 2015 Brazilian Association of Sleep.en_UK
dc.relationSeetho IW, Ramirez-Torres A, Albalat A, Mullen W, Mischak H, Parker RJ, Craig S, Duffy N, Hardy KJ, Burniston JG & Wilding JPH (2015) Urinary proteomic profiling in severe obesity and obstructive sleep apnoea with CPAP treatment. Sleep Science, 8 (2), pp. 58-67.
dc.rightsCopyright 2015 Brazilian Association of Sleep. Production and Hosting by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (
dc.subjectObstructive sleep apnoeaen_UK
dc.subjectSevere obesityen_UK
dc.subjectUrinary proteomicsen_UK
dc.titleUrinary proteomic profiling in severe obesity and obstructive sleep apnoea with CPAP treatmenten_UK
dc.typeJournal Articleen_UK
dc.citation.jtitleSleep Scienceen_UK
dc.type.statusVoR - Version of Recorden_UK
dc.contributor.affiliationUniversity of Liverpoolen_UK
dc.contributor.affiliationUniversity of Glasgowen_UK
dc.contributor.affiliationComplex Systems - LEGACYen_UK
dc.contributor.affiliationUniversity of Glasgowen_UK
dc.contributor.affiliationUniversity of Glasgowen_UK
dc.contributor.affiliationAintree University Hospital NHSen_UK
dc.contributor.affiliationAintree University Hospital NHSen_UK
dc.contributor.affiliationAintree University Hospital NHSen_UK
dc.contributor.affiliationSt Helens and Knowsley Hospitals NHSen_UK
dc.contributor.affiliationLiverpool John Moores Universityen_UK
dc.contributor.affiliationUniversity of Liverpoolen_UK
rioxxterms.apcnot requireden_UK
rioxxterms.typeJournal Article/Reviewen_UK
local.rioxx.authorSeetho, Ian W|en_UK
local.rioxx.authorRamirez-Torres, Adela|en_UK
local.rioxx.authorAlbalat, Amaya|0000-0002-8606-2995en_UK
local.rioxx.authorMullen, William|en_UK
local.rioxx.authorMischak, Harald|en_UK
local.rioxx.authorParker, Robert J|en_UK
local.rioxx.authorCraig, Sonya|en_UK
local.rioxx.authorDuffy, Nick|en_UK
local.rioxx.authorHardy, Kevin J|en_UK
local.rioxx.authorBurniston, Jatin G|en_UK
local.rioxx.authorWilding, John P H|en_UK
local.rioxx.projectInternal Project|University of Stirling|
Appears in Collections:Aquaculture Journal Articles

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