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dc.contributor.authorSeetho, Ian Wen_UK
dc.contributor.authorSiwy, Justynaen_UK
dc.contributor.authorAlbalat, Amayaen_UK
dc.contributor.authorMullen, Williamen_UK
dc.contributor.authorMischak, Haralden_UK
dc.contributor.authorParker, Robert Jen_UK
dc.contributor.authorCraig, Sonyaen_UK
dc.contributor.authorDuffy, Nicken_UK
dc.contributor.authorHardy, Kevin Jen_UK
dc.contributor.authorBurniston, Jatin Gen_UK
dc.contributor.authorWilding, John P Hen_UK
dc.description.abstractBackground:  Obstructive sleep apnoea (OSA) is a common complication of obesity and can have a substantial negative impact on a patient's quality of life and risk of cardiovascular disease. The aim of this case-control study was to undertake discovery profiling of urinary peptides using capillary electrophoresis-mass spectrometry (CE-MS) in obese subjects with and without OSA, without a history of coronary artery disease.  Materials and methods:  Urinary samples were analysed by CE-MS. Body composition and blood pressure measurements were recorded. Overnight polysomnography was conducted to confirm or refute OSA. OSA patients were naïve to continuous positive airway pressure treatment.  Results:  Sixty-one subjects with OSA (age 47 ± 9 years, BMI 43 ± 8 kg/m2) and 31 controls (age 49 ± 10 years, BMI 40 ± 5 kg/m2) were studied; P = ns for age and BMI. Apnoea-hypopnoea Index was higher in patients with OSA (24 ± 18·6) than controls without OSA (non-OSA) (2·6 ± 1·1; P < 0·0001). Metabolic syndrome was present in 35 (57%) of those with OSA compared with 4 (13%) of controls (P < 0·0001). Twenty-four polypeptides were candidates for differential distribution (P < 0·01), although these differences did not reach significance after multiple testing. Sequences were determined for eight peptides demonstrating origins from collagens and fibrinogen alpha.  Conclusions:  In this study, we report for the first time, urinary proteomic profile analyses using CE-MS in OSA and non-OSA obese groups. The differences in urinary proteomic profiles prior to adjustment for multiple testing, with increased metabolic syndrome in obese OSA subjects, suggest that there may be a role for CE-MS in characterising urinary profiles in severely obese populations with OSA. © 2014 Stichting European Society for Clinical Investigation Journal Foundation.en_UK
dc.publisherWiley-Blackwell for Stichting European Society for Clinical Investigation Journal Foundationen_UK
dc.relationSeetho IW, Siwy J, Albalat A, Mullen W, Mischak H, Parker RJ, Craig S, Duffy N, Hardy KJ, Burniston JG & Wilding JPH (2014) Urinary proteomics in obstructive sleep apnoea and obesity. European Journal of Clinical Investigation, 44 (11), pp. 1104-1115.
dc.rightsThe publisher does not allow this work to be made publicly available in this Repository. Please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study.en_UK
dc.subjectobstructive sleep apnoeaen_UK
dc.subjecturinary proteomicsen_UK
dc.titleUrinary proteomics in obstructive sleep apnoea and obesityen_UK
dc.typeJournal Articleen_UK
dc.rights.embargoreason[Seetho_et_al-2014-European_Journal_of_Clinical_Investigation.pdf] The publisher does not allow this work to be made publicly available in this Repository therefore there is an embargo on the full text of the work.en_UK
dc.citation.jtitleEuropean Journal of Clinical Investigationen_UK
dc.type.statusVoR - Version of Recorden_UK
dc.contributor.affiliationUniversity of Liverpoolen_UK
dc.contributor.affiliationMosaiques Diagnostics and Therapeutics AGen_UK
dc.contributor.affiliationComplex Systems - LEGACYen_UK
dc.contributor.affiliationUniversity of Glasgowen_UK
dc.contributor.affiliationUniversity of Glasgowen_UK
dc.contributor.affiliationAintree University Hospital NHSen_UK
dc.contributor.affiliationAintree University Hospital NHSen_UK
dc.contributor.affiliationAintree University Hospital NHSen_UK
dc.contributor.affiliationSt Helens and Knowsley Hospitals NHSen_UK
dc.contributor.affiliationLiverpool John Moores Universityen_UK
dc.contributor.affiliationUniversity of Liverpoolen_UK
rioxxterms.apcnot requireden_UK
rioxxterms.typeJournal Article/Reviewen_UK
local.rioxx.authorSeetho, Ian W|en_UK
local.rioxx.authorSiwy, Justyna|en_UK
local.rioxx.authorAlbalat, Amaya|0000-0002-8606-2995en_UK
local.rioxx.authorMullen, William|en_UK
local.rioxx.authorMischak, Harald|en_UK
local.rioxx.authorParker, Robert J|en_UK
local.rioxx.authorCraig, Sonya|en_UK
local.rioxx.authorDuffy, Nick|en_UK
local.rioxx.authorHardy, Kevin J|en_UK
local.rioxx.authorBurniston, Jatin G|en_UK
local.rioxx.authorWilding, John P H|en_UK
local.rioxx.projectInternal Project|University of Stirling|
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