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dc.contributor.authorVierna, Joaquinen_UK
dc.contributor.authorWehner, Stefanieen_UK
dc.contributor.authordu Siederdissen, Christian Honeren_UK
dc.contributor.authorMartinez-Lage, Andresen_UK
dc.contributor.authorMarz, Manjaen_UK
dc.description.abstractSeveral studies on 5S ribosomal DNA (5S rDNA) have been focused on a subset of the following features in mostly one organism: number of copies, pseudogenes, secondary structure, promoter and terminator characteristics, genomic arrangements, types of non-transcribed spacers and evolution. In this work, we systematically analyzed 5S rDNA sequence diversity in available metazoan genomes, and showed organism-specific and evolutionary-conserved features. Putatively functional sequences (12 766) from 97 organisms allowed us to identify general features of this multigene family in animals. Interestingly, we show that each mammal species has a highly conserved (housekeeping) 5S rRNA type and many variable ones. The genomic organization of 5S rDNA is still under debate. Here, we report the occurrence of several paralog 5S rRNA sequences in 58 of the examined species, and a flexible genome organization of 5S rDNA in animals. We found heterogeneous 5S rDNA clusters in several species, supporting the hypothesis of an exchange of 5S rDNA from one locus to another. A rather high degree of variation of upstream, internal and downstream putative regulatory regions appears to characterize metazoan 5S rDNA. We systematically studied the internal promoters and described three different types of termination signals, as well as variable distances between the coding region and the typical termination signal. Finally, we present a statistical method for detection of linkage among noncoding RNA (ncRNA) gene families. This method showed no evolutionary-conserved linkage among 5S rDNAs and any other ncRNA genes within Metazoa, even though we found 5S rDNA to be linked to various ncRNAs in several clades.en_UK
dc.publisherSpringer Nature for the Genetics Societyen_UK
dc.relationVierna J, Wehner S, du Siederdissen CH, Martinez-Lage A & Marz M (2013) Systematic analysis and evolution of 5S ribosomal DNA in metazoans. Heredity, 111 (5), pp. 410-421.
dc.rightsThe publisher does not allow this work to be made publicly available in this Repository. Please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study.en_UK
dc.subject5S rRNAen_UK
dc.subjecthomologous genesen_UK
dc.subjectnoncoding RNAen_UK
dc.subjectsecondary structureen_UK
dc.subjectbirth-and-death evolutionen_UK
dc.titleSystematic analysis and evolution of 5S ribosomal DNA in metazoansen_UK
dc.typeJournal Articleen_UK
dc.rights.embargoreason[hdy201363a.pdf] The publisher does not allow this work to be made publicly available in this Repository therefore there is an embargo on the full text of the work.en_UK
dc.type.statusVoR - Version of Recorden_UK
dc.contributor.affiliationUniversity of Corunaen_UK
dc.contributor.affiliationInstitute of Aquacultureen_UK
dc.contributor.affiliationUniversity of Viennaen_UK
dc.contributor.affiliationUniversity of Corunaen_UK
dc.contributor.affiliationPhilipps University of Marburgen_UK
rioxxterms.typeJournal Article/Reviewen_UK
local.rioxx.authorVierna, Joaquin|en_UK
local.rioxx.authorWehner, Stefanie|0000-0002-3632-2584en_UK
local.rioxx.authordu Siederdissen, Christian Honer|en_UK
local.rioxx.authorMartinez-Lage, Andres|en_UK
local.rioxx.authorMarz, Manja|en_UK
local.rioxx.projectInternal Project|University of Stirling|
Appears in Collections:Aquaculture Journal Articles

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