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dc.contributor.authorValenzuela-Munoz, Valentinaen_UK
dc.contributor.authorSturm, Arminen_UK
dc.contributor.authorGallardo-Escarate, Cristianen_UK
dc.description.abstractBackground  ATP-binding cassette (ABC) protein family encode for membrane proteins involved in the transport of various biomolecules through the cellular membrane. These proteins have been identified in all taxa and present important physiological functions, including the process of insecticide detoxification in arthropods. For that reason the ectoparasiteCaligus rogercresseyirepresents a model species for understanding the molecular underpinnings involved in insecticide drug resistance.  Methods  llumina sequencing was performed using sea lice exposed to 2 and 3 ppb of deltamethrin and azamethiphos. Contigs obtained fromde novoassembly were annotated by Blastx. RNA-Seq analysis was performed and validated by qPCR analysis.  Results  From the transcriptome database ofC. rogercresseyi, 57 putative members of ABC protein sequences were identified and phylogenetically classified into the eight subfamilies described for ABC transporters in arthropods. Transcriptomic profiles for ABC proteins subfamilies were evaluated throughoutC. rogercresseyidevelopment. Moreover, RNA-Seq analysis was performed for adult male and female salmon lice exposed to the delousing drugs azamethiphos and deltamethrin. High transcript levels of the ABCB and ABCC subfamilies were evidenced. Furthermore, SNPs mining was carried out for the ABC proteins sequences, revealing pivotal genomic information.  Conclusions  The present study gives a comprehensive transcriptome analysis of ABC proteins fromC. rogercresseyi,providing relevant information about transporter roles during ontogeny and in relation to delousing drug responses in salmon lice. This genomic information represents a valuable tool for pest management in the Chilean salmon aquaculture industry.en_UK
dc.publisherBioMed Centralen_UK
dc.relationValenzuela-Munoz V, Sturm A & Gallardo-Escarate C (2015) Transcriptomic insights on the ABC transporter gene family in the salmon louse Caligus rogercresseyi. Parasites and Vectors, 8, Art. No.: 209.
dc.rights© Valenzuela-Muñoz et al.; licensee BioMed Central. 2015 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated.en_UK
dc.subjectCaligus rogercresseyien_UK
dc.subjectABC transportersen_UK
dc.titleTranscriptomic insights on the ABC transporter gene family in the salmon louse Caligus rogercresseyien_UK
dc.typeJournal Articleen_UK
dc.citation.jtitleParasites and Vectorsen_UK
dc.type.statusVoR - Version of Recorden_UK
dc.contributor.affiliationUniversity of Concepcionen_UK
dc.contributor.affiliationInstitute of Aquacultureen_UK
dc.contributor.affiliationUniversity of Concepcionen_UK
rioxxterms.apcnot requireden_UK
rioxxterms.typeJournal Article/Reviewen_UK
local.rioxx.authorValenzuela-Munoz, Valentina|en_UK
local.rioxx.authorSturm, Armin|0000-0003-2632-1999en_UK
local.rioxx.authorGallardo-Escarate, Cristian|en_UK
local.rioxx.projectInternal Project|University of Stirling|
Appears in Collections:Aquaculture Journal Articles

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