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Appears in Collections:Computing Science and Mathematics Journal Articles
Peer Review Status: Refereed
Title: A novel ontology and machine learning driven hybrid cardiovascular clinical prognosis as a complex adaptive clinical system
Author(s): Farooq, Kamran
Hussain, Amir
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Keywords: Clinical decision support framework
Cardiovascular decision support framework
Hybrid clinical decision support framework
Issue Date: Dec-2016
Date Deposited: 12-Aug-2016
Citation: Farooq K & Hussain A (2016) A novel ontology and machine learning driven hybrid cardiovascular clinical prognosis as a complex adaptive clinical system. Complex Adaptive Systems Modeling, 4, Art. No.: 12.
Abstract: Purpose  This multidisciplinary industrial research project sets out to develop a hybrid clinical decision support mechanism (inspired by ontology and machine learning driven techniques) by combining evidence, extrapolated through legacy patient data to facilitate cardiovascular preventative care.  Methods  The proposed cardiovascular clinical decision support framework comprises of two novel key components: (1) Ontology driven clinical risk assessment and recommendation system (ODCRARS) (2) Machine learning driven prognostic system (MLDPS). State of the art machine learning and feature selection methods are utilised for the prognostic modelling purposes. The ODCRARS is a knowledge-based system which is based on clinical expert’s knowledge, encoded in the form of clinical rules engine to carry out cardiac risk assessment for various cardiovascular diseases. The MLDPS is a non knowledge-based/data driven system which is developed using state of the art machine learning and feature selection techniques applied on real patient datasets. Clinical case studies in the RACPC, heart disease and breast cancer domains are considered for the development and clinical validation purposes. For the purpose of this paper, clinical case study in the RACPC/chest pain domain will be discussed in detail from the development and validation perspective.  Results  The proposed clinical decision support framework is validated through clinical case studies in the cardiovascular domain. This paper demonstrates an effective cardiovascular decision support mechanism for handling inaccuracies in the clinical risk assessment of chest pain patients and help clinicians effectively distinguish acute angina/cardiac chest pain patients from those with other causes of chest pain.  Conclusion  The new clinical models, having been evaluated in clinical practice, resulted in very good predictive power, demonstrating general performance improvement over benchmark multivariate statistical classifiers. Various chest pain risk assessment prototypes have been developed and deployed online for further clinical trials.
DOI Link: 10.1186/s40294-016-0023-x
Rights: © 2016 The Author(s). This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (, which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
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