Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/2389
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dc.contributor.authorHall, Jeremyen_UK
dc.contributor.authorWhalley, Heather Cen_UK
dc.contributor.authorMcKirdy, James Wen_UK
dc.contributor.authorRomaniuk, Lianaen_UK
dc.contributor.authorMcGonigle, Daviden_UK
dc.contributor.authorMcIntosh, Andrew Men_UK
dc.contributor.authorBaig, Ben Jen_UK
dc.contributor.authorGountouna, Viktoria-Elenien_UK
dc.contributor.authorJob, Dominic Een_UK
dc.contributor.authorDonaldson, Daviden_UK
dc.contributor.authorSprengelmeyer, Reineren_UK
dc.contributor.authorYoung, Andrew Wen_UK
dc.contributor.authorJohnstone, Eve Cen_UK
dc.contributor.authorLawrie, Stephen Men_UK
dc.date.accessioned2016-11-30T23:21:40Z-
dc.date.available2016-11-30T23:21:40Z-
dc.date.issued2008-07-01en_UK
dc.identifier.urihttp://hdl.handle.net/1893/2389-
dc.description.abstractBackground The amygdala plays a central role in detecting and responding to fear-related stimuli. A number of recent studies have reported decreased amygdala activation in schizophrenia to emotional stimuli (such as fearful faces) compared with matched neutral stimuli (such as neutral faces). We investigated whether the apparent decrease in amygdala activation in schizophrenia could actually derive from increased amygdala activation to the neutral comparator stimuli. Methods Nineteen patients with schizophrenia and 24 matched control participants viewed pictures of faces with either fearful or neutral facial expressions, and a baseline condition, during functional magnetic resonance imaging scanning. Results Patients with schizophrenia showed a relative decrease in amygdala activation to fearful faces compared with neutral faces. However, this difference resulted from an increase in amygdala activation to the neutral faces in patients with schizophrenia, not from a decreased response to the fearful faces. Conclusions Patients with schizophrenia show an increased response of the amygdala to neutral faces. This is sufficient to explain their apparent deficit in amygdala activation to fearful faces compared with neutral faces. The inappropriate activation of neural systems involved in fear to otherwise neutral stimuli may contribute to the development of psychotic symptoms in schizophrenia.en_UK
dc.language.isoenen_UK
dc.publisherElsevier / Society of Biological Psychiatryen_UK
dc.relationHall J, Whalley HC, McKirdy JW, Romaniuk L, McGonigle D, McIntosh AM, Baig BJ, Gountouna V, Job DE, Donaldson D, Sprengelmeyer R, Young AW, Johnstone EC & Lawrie SM (2008) Overactivation of fear systems to neutral faces in schizophrenia. Biological Psychiatry, 64 (1), pp. 70-73. http://www.sciencedirect.com/science/journal/00063223; https://doi.org/10.1016/j.biopsych.2007.12.014en_UK
dc.rightsPublished in Biological Psychiatry by Elsevier / Society of Biological Psychiatry.en_UK
dc.subjectAmygdalaen_UK
dc.subjectemotionen_UK
dc.subjectfaceen_UK
dc.subjectfearen_UK
dc.subjectfMRIen_UK
dc.subjectschizophreniaen_UK
dc.subjectFacial expression Physiological aspects.en_UK
dc.subjectAmygdaloid bodyen_UK
dc.subjectSchizophrenia Case studiesen_UK
dc.titleOveractivation of fear systems to neutral faces in schizophreniaen_UK
dc.typeJournal Articleen_UK
dc.identifier.doi10.1016/j.biopsych.2007.12.014en_UK
dc.citation.jtitleBiological Psychiatryen_UK
dc.citation.issn0006-3223en_UK
dc.citation.volume64en_UK
dc.citation.issue1en_UK
dc.citation.spage70en_UK
dc.citation.epage73en_UK
dc.citation.publicationstatusPublisheden_UK
dc.citation.peerreviewedRefereeden_UK
dc.type.statusAM - Accepted Manuscripten_UK
dc.identifier.urlhttp://www.sciencedirect.com/science/journal/00063223en_UK
dc.author.emaildid1@stir.ac.uken_UK
dc.citation.date04/03/2008en_UK
dc.contributor.affiliationUniversity of Edinburghen_UK
dc.contributor.affiliationUniversity of Edinburghen_UK
dc.contributor.affiliationUniversity of Edinburghen_UK
dc.contributor.affiliationUniversity of Edinburghen_UK
dc.contributor.affiliationCardiff Universityen_UK
dc.contributor.affiliationUniversity of Edinburghen_UK
dc.contributor.affiliationUniversity of Edinburghen_UK
dc.contributor.affiliationUniversity of Edinburghen_UK
dc.contributor.affiliationUniversity of Edinburghen_UK
dc.contributor.affiliationPsychologyen_UK
dc.contributor.affiliationUniversity of St Andrewsen_UK
dc.contributor.affiliationUniversity of Yorken_UK
dc.contributor.affiliationUniversity of Edinburghen_UK
dc.contributor.affiliationUniversity of Edinburghen_UK
dc.identifier.isiWOS:000256785500010en_UK
dc.identifier.scopusid2-s2.0-44749083120en_UK
dc.identifier.wtid811614en_UK
dc.contributor.orcid0000-0002-8036-3455en_UK
dcterms.dateAccepted2008-03-04en_UK
dc.date.filedepositdate2010-07-27en_UK
rioxxterms.typeJournal Article/Reviewen_UK
rioxxterms.versionAMen_UK
local.rioxx.authorHall, Jeremy|en_UK
local.rioxx.authorWhalley, Heather C|en_UK
local.rioxx.authorMcKirdy, James W|en_UK
local.rioxx.authorRomaniuk, Liana|en_UK
local.rioxx.authorMcGonigle, David|en_UK
local.rioxx.authorMcIntosh, Andrew M|en_UK
local.rioxx.authorBaig, Ben J|en_UK
local.rioxx.authorGountouna, Viktoria-Eleni|en_UK
local.rioxx.authorJob, Dominic E|en_UK
local.rioxx.authorDonaldson, David|0000-0002-8036-3455en_UK
local.rioxx.authorSprengelmeyer, Reiner|en_UK
local.rioxx.authorYoung, Andrew W|en_UK
local.rioxx.authorJohnstone, Eve C|en_UK
local.rioxx.authorLawrie, Stephen M|en_UK
local.rioxx.projectInternal Project|University of Stirling|https://isni.org/isni/0000000122484331en_UK
local.rioxx.freetoreaddate2010-07-27en_UK
local.rioxx.licencehttp://www.rioxx.net/licenses/all-rights-reserved|2010-07-27|en_UK
local.rioxx.filenameDonaldson7.pdfen_UK
local.rioxx.filecount1en_UK
local.rioxx.source0006-3223en_UK
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