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Appears in Collections:Psychology Journal Articles
Peer Review Status: Refereed
Title: Neural Activation Patterns of Successful Episodic Encoding: Reorganization During Childhood, Maintenance in Old Age
Author(s): Shing, Yee Lee
Brehmer, Yvonne
Heekeren, Hauke R
Backman, Lars
Lindenberger, Ulman
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Keywords: Aging
Episodic Memory
subsequent memory
Issue Date: Aug-2016
Date Deposited: 27-Jun-2016
Citation: Shing YL, Brehmer Y, Heekeren HR, Backman L & Lindenberger U (2016) Neural Activation Patterns of Successful Episodic Encoding: Reorganization During Childhood, Maintenance in Old Age. Developmental Cognitive Neuroscience, 20, pp. 59-69.
Abstract: The two-component framework of episodic memory (EM) development posits that the contributions of medial temporal lobe (MTL) and prefrontal cortex (PFC) to successful encoding differ across the lifespan. To test the framework’s hypotheses, we compared subsequent memory effects (SME) of 10-12 year-old children, younger adults, and older adults using functional magnetic resonance imaging (fMRI). Memory was probed by cued recall, and SME were defined as regional activation differences during encoding between subsequently correctly recalled versus omitted items. In MTL areas, children’s SME did not differ in magnitude from those of younger and older adults. In contrast, children’s SME in PFC were weaker than the corresponding SME in younger and older adults, in line with the hypothesis that PFC contributes less to successful encoding in childhood. Differences in SME between younger and older adults were negligible. The present results suggest that, among individuals with high memory functioning, the neural circuitry contributing to successful episodic encoding is reorganized from middle childhood to adulthood. Successful episodic encoding in later adulthood, however, is characterized by the ability to maintain the activation patterns that emerged in young adulthood.
DOI Link: 10.1016/j.dcn.2016.06.003
Rights: © 2016 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (
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