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Appears in Collections:Psychology Journal Articles
Peer Review Status: Refereed
Title: Neural activation patterns during retrieval of schema-related memories: Differences and commonalities between children and adults
Author(s): Brod, Garvin
Lindenberger, Ulman
Shing, Yee Lee
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Issue Date: Nov-2017
Citation: Brod G, Lindenberger U & Shing YL (2017) Neural activation patterns during retrieval of schema-related memories: Differences and commonalities between children and adults, Developmental Science, 20 (6), Art. No.: e12475.
Abstract: Schemas represent stable properties of individuals’ experiences, and allow to classify new events as being congruent or incongruent with existing knowledge. Research with adults indicates that the prefrontal cortex (PFC) is involved in memory retrieval of schema-related information. However, developmental differences between children and adults in the neural correlates of schema-related memories are not well understood. One reason for this is the inherent confound between schema-relevant experience and maturation, as both are related to time. To overcome this limitation, we used a novel paradigm that experimentally induces, and then probes for task-relevant knowledge during encoding of new information. Thirty-one children aged 8–12 years and 26 young adults participated in the experiment. While successfully retrieving schema-congruent events, children showed less medial PFC activity than adults. In addition, medial PFC activity during successful retrieval correlated positively with children’s age. While successfully retrieving schema-incongruent events, children showed stronger hippocampus (HC) activation as well as weaker connectivity between the striatum and the dorsolateral PFC than adults. These findings were corroborated by an exploratory full-factorial analysis investigating age differences in the retrieval of schemacongruent versus schema-incongruent events, comparing the two conditions directly. Consistent with the findings of the separate analyses, two clusters, one in the medial PFC, one in the HC, were identified that exhibited a memory x congruency x age group interaction. In line with the two-component model of episodic memory development, the present findings point to an age-related shift from a more HC-bound processing to an increasing recruitment of prefrontal brain regions in the retrieval of schema-related events.
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Rights: This item has been embargoed for a period. During the embargo please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study. This is the peer reviewed version of the following article: Sjölund MJ, González-Díaz P, Moreno-Villena JJ, Jump AS. Brod, G., Lindenberger, U. and Shing, Y. L. (2017), Neural activation patterns during retrieval of schema-related memories: differences and commonalities between children and adults. Dev Sci, 20: n/a, e12475, which has been published in final form at This article may be used for non-commercial purposes in accordance With Wiley Terms and Conditions for self-archiving.

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