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Appears in Collections:Psychology Journal Articles
Peer Review Status: Refereed
Title: Place cells on a maze encode routes rather than destinations
Author(s): Grieves, Roddy M
Wood, Emma R
Dudchenko, Paul A
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Keywords: hippocampus
place cell
spatial memory
trajectory encoding
Issue Date: 2016
Date Deposited: 22-Jun-2016
Citation: Grieves RM, Wood ER & Dudchenko PA (2016) Place cells on a maze encode routes rather than destinations. eLife, 5, Art. No.: e15986.
Abstract: Hippocampal place cells fire at different rates when a rodent runs through a given location on its way to different destinations. However, it is unclear whether such firing represents the animal's intended destination or the execution of a specific trajectory. To distinguish between these possibilities, Lister Hooded rats (n=8) were trained to navigate from a start box to three goal locations via four partially overlapping routes. Two of these led to the same goal location. Of the cells that fired on these two routes, 95.8% showed route-dependent firing (firing on only one route), whereas only two cells (4.2%) showed goal-dependent firing (firing similarly on both routes). In addition, route-dependent place cells over-represented the less discriminable routes, and place cells in general over-represented the start location. These results indicate that place cell firing on overlapping routes reflects the animal's route, not its goals, and that this firing may aid spatial discrimination.
DOI Link: 10.7554/eLife.15986
Rights: Published under a Creative Commons Attribution licence (CC BY 4.0). You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
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