|Appears in Collections:||Psychology Journal Articles|
|Peer Review Status:||Refereed|
|Title:||Cortisol levels and suicidal behavior: A meta-analysis|
|Author(s):||O'Connor, Daryl B|
Green, Jessica A
O'Connor, Rory C
|Citation:||O'Connor DB, Ferguson E, Green JA, O'Carroll R & O'Connor RC (2016) Cortisol levels and suicidal behavior: A meta-analysis, Psychoneuroendocrinology, 63, pp. 370-379. https://doi.org/10.1016/j.psyneuen.2015.10.011.|
|Abstract:||Suicide is a major cause of death worldwide, responsible for 1.5% of all mortality. The causes of suicidal behavior are not fully understood. Dysregulatedhypothalamic–pituitary–adrenal (HPA) axis activity, as measured bycortisollevels, is one potential risk factor. This meta-analytic review aimed (i) to estimate the strength and variability of the association between naturally fluctuating cortisol levels and suicidal behavior and (ii) to identify moderators of this relationship. A systematic literature search identified 27 studies (N=2226; 779 suicide attempters and 1447 non-attempters) that met the study eligibility criteria from a total of 417 unique records initially examined. Estimates of effect sizes (r) obtained from these studies were analysed using ComprehensiveMeta-Analysis. In these analyses, we compared participants identified as having a past history of suicide attempt(s) to those with no such history. Study quality, mean age of sample and percentage of male participants were examined as potential moderators. Overall, there was no significant effect of suicide group on cortisol. However, significant associations between cortisol and suicide attempts were observed as a function of age. In studies where the mean age of the sample was below 40 years the association was positive (i.e., higher cortisol was associated with suicide attempts;r=.234,p<.001), and where the mean age was 40 or above the association was negative (i.e., lower cortisol was associated with suicide attempts;r=−.129,p<.001). These findings confirm thatHPA axisactivity, as indicated by age-dependent variations in cortisol levels, is associated with suicidal behavior. The challenge for theory and clinical practice is to explain the complete reversal of the association with age and to identify its clinical implications.|
|Rights:||The publisher does not allow this work to be made publicly available in this Repository. Please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study.|
|Psychoneuroendocrinology 2016 O'Connor.pdf||Fulltext - Published Version||405.49 kB||Adobe PDF||Under Embargo until 2999-12-19 Request a copy|
Note: If any of the files in this item are currently embargoed, you can request a copy directly from the author by clicking the padlock icon above. However, this facility is dependent on the depositor still being contactable at their original email address.
This item is protected by original copyright
Items in the Repository are protected by copyright, with all rights reserved, unless otherwise indicated.
If you believe that any material held in STORRE infringes copyright, please contact email@example.com providing details and we will remove the Work from public display in STORRE and investigate your claim.