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dc.contributor.authorCallol, Agnesen_UK
dc.contributor.authorPajuelo, Daviden_UK
dc.contributor.authorEbbesson, Larsen_UK
dc.contributor.authorTeles, Marianaen_UK
dc.contributor.authorMacKenzie, Simonen_UK
dc.contributor.authorAmaro, Carmenen_UK
dc.description.abstractVibrio vulnificus is an aquatic gram-negative bacterium that causes a systemic disease in eels called warm-water vibriosis. Natural disease occurs via water born infection; bacteria attach to the gills (the main portal of entry) and spread to the internal organs through the bloodstream, provoking host death by haemorrhagic septicaemia. V.vulnificus produces a toxin called RtxA13 that hypothetically interferes with the eel immune system facilitating bacterial invasion and subsequent death by septic shock. The aim of this work was to study the early steps of warm-water vibriosis by analysing the expression of three marker mRNA transcripts related to pathogen recognition (tlr2 and tlr5) and inflammation (il-8) in the gills of eels infected by immersion with either the pathogen or a mutant deficient in rtxA13. Results indicate a differential response that is linked to the rtx toxin in the expression levels of the three measured mRNA transcripts. The results suggest that eels are able to distinguish innocuous from harmful microorganisms by the local action of their toxins rather than by surface antigens. Finally, the cells that express these transcripts in the gills are migratory cells primarily located in the second lamellae that re-locate during infection suggesting the activation of a specific immune response to pathogen invasion in the gill.en_UK
dc.relationCallol A, Pajuelo D, Ebbesson L, Teles M, MacKenzie S & Amaro C (2015) Early steps in the European eel (Anguilla anguilla)-Vibrio vulnificus interaction in the gills: role of the RtxA13 toxin. Fish and Shellfish Immunology, 43 (2), pp. 502-509.
dc.rightsThe publisher does not allow this work to be made publicly available in this Repository. Please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study.en_UK
dc.subjectEuropean eelen_UK
dc.subjectVibrio vulnificusen_UK
dc.subjectHost-pathogen relationshipen_UK
dc.subjectImmune responseen_UK
dc.titleEarly steps in the European eel (Anguilla anguilla)-Vibrio vulnificus interaction in the gills: role of the RtxA13 toxinen_UK
dc.typeJournal Articleen_UK
dc.rights.embargoreason[1-s2.0-S1050464815000108-main.pdf] The publisher does not allow this work to be made publicly available in this Repository therefore there is an embargo on the full text of the work.en_UK
dc.citation.jtitleFish and Shellfish Immunologyen_UK
dc.type.statusVoR - Version of Recorden_UK
dc.contributor.affiliationUniversitat Autonoma de Barcelonaen_UK
dc.contributor.affiliationUniversity of Valenciaen_UK
dc.contributor.affiliationUniversity of Bergenen_UK
dc.contributor.affiliationUniversitat Autonoma de Barcelonaen_UK
dc.contributor.affiliationInstitute of Aquacultureen_UK
dc.contributor.affiliationUniversity of Valenciaen_UK
rioxxterms.apcnot requireden_UK
rioxxterms.typeJournal Article/Reviewen_UK
local.rioxx.authorCallol, Agnes|en_UK
local.rioxx.authorPajuelo, David|en_UK
local.rioxx.authorEbbesson, Lars|en_UK
local.rioxx.authorTeles, Mariana|en_UK
local.rioxx.authorMacKenzie, Simon|0000-0003-1845-6826en_UK
local.rioxx.authorAmaro, Carmen|en_UK
local.rioxx.projectInternal Project|University of Stirling|
Appears in Collections:Aquaculture Journal Articles

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