Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/23335
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dc.contributor.authorBoltana, Sebastianen_UK
dc.contributor.authorValenzuela-Miranda, Diegoen_UK
dc.contributor.authorAguilar, Andreaen_UK
dc.contributor.authorMacKenzie, Simonen_UK
dc.contributor.authorGallardo-Escarate, Cristianen_UK
dc.date.accessioned2016-12-24T02:47:06Z-
dc.date.available2016-12-24T02:47:06Z-
dc.date.issued2016en_UK
dc.identifier.other22698en_UK
dc.identifier.urihttp://hdl.handle.net/1893/23335-
dc.description.abstractDespite evidence for participation in the host response to infection, the roles of many long non-coding RNAs (lncRNAs) remain unknown. Therefore, the aims of this study were to identify lncRNAs in Atlantic salmon (Salmo salar) and evaluate their transcriptomic regulation during ISA virus (ISAV) infection, an Orthomyxoviridae virus associated with high mortalities in salmonid aquaculture. Using next-generation sequencing, whole-transcriptome analysis of theSalmo salarresponse to ISAV infection was performed, identifying 5,636 putative lncRNAs with a mean length of 695 base pairs. The transcriptional modulation evidenced a similar number of differentially expressed lncRNAs in the gills (3,294), head-kidney (3,275), and liver (3,325) over the course of the infection. Moreover, analysis of a subset of these lncRNAs showed the following: (i) Most were similarly regulated in response to ISA virus infection; (ii) The transcript subsets were uniquely modulated in each tissue (gills, liver, and head-kidney); and (iii) A subset of lncRNAs were upregulated for each tissue and time analysed, indicating potential markers for ISAV infection. These findings represent the first discovery of widespread differential expression of lncRNAs in response to virus infection in non-model species, suggesting that lncRNAs could be involved in regulating the host response during ISAV infection.en_UK
dc.language.isoenen_UK
dc.publisherNature Publishing groupen_UK
dc.relationBoltana S, Valenzuela-Miranda D, Aguilar A, MacKenzie S & Gallardo-Escarate C (2016) Long noncoding RNAs (lncRNAs) dynamics evidence immunomodulation during ISAV-Infected Atlantic salmon (Salmo salar). Scientific Reports, 6 (4), Art. No.: 22698. https://doi.org/10.1038/srep22698en_UK
dc.rightsThis work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/en_UK
dc.titleLong noncoding RNAs (lncRNAs) dynamics evidence immunomodulation during ISAV-Infected Atlantic salmon (Salmo salar)en_UK
dc.typeJournal Articleen_UK
dc.identifier.doi10.1038/srep22698en_UK
dc.identifier.pmid26939752en_UK
dc.citation.jtitleScientific Reportsen_UK
dc.citation.issn2045-2322en_UK
dc.citation.volume6en_UK
dc.citation.issue4en_UK
dc.citation.publicationstatusPublisheden_UK
dc.citation.peerreviewedRefereeden_UK
dc.type.statusVoR - Version of Recorden_UK
dc.author.emailsm161@stir.ac.uken_UK
dc.citation.date04/03/2016en_UK
dc.contributor.affiliationUniversity of Concepcionen_UK
dc.contributor.affiliationUniversity of Concepcionen_UK
dc.contributor.affiliationUniversity of Concepcionen_UK
dc.contributor.affiliationInstitute of Aquacultureen_UK
dc.contributor.affiliationUniversity of Concepcionen_UK
dc.identifier.isiWOS:000371524200002en_UK
dc.identifier.scopusid2-s2.0-84960481760en_UK
dc.identifier.wtid567381en_UK
dc.contributor.orcid0000-0003-1845-6826en_UK
dc.date.accepted2016-02-18en_UK
dc.date.filedepositdate2016-06-16en_UK
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