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dc.contributor.authorMonroig, Oscaren_UK
dc.contributor.authorLopes-Marques, Mónicaen_UK
dc.contributor.authorNavarro, Juan Carlosen_UK
dc.contributor.authorHontoria, Franciscoen_UK
dc.contributor.authorRuvio, Raquelen_UK
dc.contributor.authorSantos, Miguelen_UK
dc.contributor.authorVenkatesh, Byrappaen_UK
dc.contributor.authorTocher, Douglas Ren_UK
dc.contributor.authorCosta Castro, Luıs Filipeen_UK
dc.description.abstractThe biosynthesis of long-chain polyunsaturated fatty acids (LC-PUFA) provides an intriguing example on how multi-enzymatic cascades evolve. Essential LC-PUFA, such as arachidonic, eicosapentaenoic, and docosahexaenoic acids (DHA), can be acquired from the diet but are also endogenously retailored from C18 precursors through consecutive elongations and desaturations catalyzed, respectively, by fatty acyl elongase and desaturase enzymes. The molecular wiring of this enzymatic pathway de nes the ability of a species to biosynthesize LC-PUFA. Exactly when and how in animal evolution a functional LC-PUFA pathway emerged is still elusive. Here we examine key components of the LC-PUFA cascade, the Elovl2/Elovl5 elongases, from amphioxus, an invertebrate chordate, the sea lamprey, a representative of agnathans, and the elephant shark, a basal jawed vertebrate. We show that Elovl2 and Elovl5 emerged from genome duplications in vertebrate ancestry. The single Elovl2/5 from amphioxus e ciently elongates C18 and C20 and, to a marked lesser extent, C22 LC-PUFA. Lamprey is incapable of elongating C22 substrates. The elephant shark Elovl2 showed that the ability to e ciently elongate C22 PUFA and thus to synthesize DHA through the Sprecher pathway, emerged in the jawed vertebrate ancestor. Our ndings illustrate how non-integrated “metabolic islands” evolve into fully wired pathways upon duplication and neofunctionalization.en_UK
dc.publisherNature Publishing Groupen_UK
dc.relationMonroig O, Lopes-Marques M, Navarro JC, Hontoria F, Ruvio R, Santos M, Venkatesh B, Tocher DR & Costa Castro LF (2016) Evolutionary functional elaboration of the Elovl2/5 gene family in chordates. Scientific Reports, 6, Art. No.: 20510.
dc.rightsThis work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit
dc.subjectLong-chain polyunsaturated fatty acidsen_UK
dc.titleEvolutionary functional elaboration of the Elovl2/5 gene family in chordatesen_UK
dc.typeJournal Articleen_UK
dc.citation.jtitleScientific Reportsen_UK
dc.type.statusVoR - Version of Recorden_UK
dc.contributor.affiliationComplex Systems - LEGACYen_UK
dc.contributor.affiliationUniversity of Portoen_UK
dc.contributor.affiliationInstitute of Aquaculture Torre de la Salen_UK
dc.contributor.affiliationInstitute of Aquaculture Torre de la Salen_UK
dc.contributor.affiliationUniversity of Portoen_UK
dc.contributor.affiliationUniversity of Portoen_UK
dc.contributor.affiliationInstitute of Molecular and Cell Biology - A*STARen_UK
dc.contributor.affiliationInstitute of Aquacultureen_UK
dc.contributor.affiliationUniversity of Portoen_UK
rioxxterms.apcnot requireden_UK
rioxxterms.typeJournal Article/Reviewen_UK
local.rioxx.authorMonroig, Oscar|0000-0001-8712-0440en_UK
local.rioxx.authorLopes-Marques, Mónica|en_UK
local.rioxx.authorNavarro, Juan Carlos|en_UK
local.rioxx.authorHontoria, Francisco|en_UK
local.rioxx.authorRuvio, Raquel|en_UK
local.rioxx.authorSantos, Miguel|en_UK
local.rioxx.authorVenkatesh, Byrappa|en_UK
local.rioxx.authorTocher, Douglas R|0000-0002-8603-9410en_UK
local.rioxx.authorCosta Castro, Luıs Filipe|en_UK
local.rioxx.projectInternal Project|University of Stirling|
local.rioxx.filenameMonroig 2016 (Elovl25 evolution).pdfen_UK
Appears in Collections:Aquaculture Journal Articles

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