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dc.contributor.authorde Brito, Anderson Fernandesen_UK
dc.contributor.authorBranconi, Carla Torresen_UK
dc.contributor.authorWeidmann, Manfreden_UK
dc.contributor.authorDilcher, Meiken_UK
dc.contributor.authorAlves, Jaoa Marcelo Pereiraen_UK
dc.contributor.authorGruber, Arthuren_UK
dc.contributor.authorZanotto, Paolo M D Aen_UK
dc.description.abstractThe alphabaculovirusAnticarsia gemmatalismultiple nucleopolyhedrovirus (AgMNPV) is the world’s most successful viral bioinsecticide. Through the 1980s and 1990s, this virus was extensively used for biological control of populations ofAnticarsia gemmatalis(Velvetbean caterpillar) in soybean crops. During this period, genetic studies identified several variable loci in the AgMNPV; however, most of them were not characterized at the sequence level. In this study we report a full genome comparison among 17 wild-type isolates of AgMNPV. We found the pangenome of this virus to contain at least 167 hypothetical genes, 151 of which are shared by all genomes. The genebro-athat might be involved in host specificity and carrying transporter is absent in some genomes, and new hypothetical genes were observed. Among these genes there is a uniquernf12-likegene, probably implicated in ubiquitination. Events of gene fission and fusion are common, as four genes have been observed as single or split open reading frames. Gains and losses of genomic fragments (from 20 to 900 bp) are observed within tandem repeats, such as in eight direct repeats and four homologous regions. Most AgMNPV genes present low nucleotide diversity, and variable genes are mainly located in a locus known to evolve through homologous recombination. The evolution of AgMNPV is mainly driven by small indels, substitutions, gain and loss of nucleotide stretches or entire coding sequences. These variations may cause relevant phenotypic alterations, which probably affect the infectivity of AgMNPV. This work provides novel information on genomic evolution of the AgMNPV in particular and of baculoviruses in general.en_UK
dc.publisherOxford University Pressen_UK
dc.relationde Brito AF, Branconi CT, Weidmann M, Dilcher M, Alves JMP, Gruber A & Zanotto PMDA (2016) The pangenome of the Anticarsia gemmatalis multiple nucleopolyhedrovirus (AgMNPV). Genome Biology and Evolution, 8 (1), pp. 94-108.
dc.rights© The Author(s) 2015. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (, which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.comen_UK
dc.subjectwild isolatesen_UK
dc.subjecthorizontal gene transferen_UK
dc.subjectdeep sequencingen_UK
dc.subjectgenetic diversityen_UK
dc.titleThe pangenome of the Anticarsia gemmatalis multiple nucleopolyhedrovirus (AgMNPV)en_UK
dc.typeJournal Articleen_UK
dc.citation.jtitleGenome Biology and Evolutionen_UK
dc.type.statusVoR - Version of Recorden_UK
dc.contributor.affiliationUniversity of Sao Pauloen_UK
dc.contributor.affiliationUniversity of Sao Pauloen_UK
dc.contributor.affiliationInstitute of Aquacultureen_UK
dc.contributor.affiliationGeorg-August University Gottingenen_UK
dc.contributor.affiliationUniversity of Sao Pauloen_UK
dc.contributor.affiliationUniversity of Sao Pauloen_UK
dc.contributor.affiliationUniversity of Sao Pauloen_UK
rioxxterms.apcnot requireden_UK
rioxxterms.typeJournal Article/Reviewen_UK
local.rioxx.authorde Brito, Anderson Fernandes|en_UK
local.rioxx.authorBranconi, Carla Torres|en_UK
local.rioxx.authorWeidmann, Manfred|0000-0002-7063-7491en_UK
local.rioxx.authorDilcher, Meik|en_UK
local.rioxx.authorAlves, Jaoa Marcelo Pereira|en_UK
local.rioxx.authorGruber, Arthur|en_UK
local.rioxx.authorZanotto, Paolo M D A|en_UK
local.rioxx.projectInternal Project|University of Stirling|
local.rioxx.filenamede Brito et al_Genome Biol Evol_2016.pdfen_UK
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