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Appears in Collections:Faculty of Health Sciences and Sport Journal Articles
Peer Review Status: Refereed
Title: Effects of chronic overload on muscle hypertrophy and mTOR signaling in young adult and aged rats
Author(s): Chale-Rush, Angela
Morris, Evan P
Kendall, Tracee L
Brooks, Naomi
Fielding, Roger A
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Keywords: mTOR
Muscle hypertrophy
Muscle overload
Issue Date: Dec-2009
Date Deposited: 17-Dec-2015
Citation: Chale-Rush A, Morris EP, Kendall TL, Brooks N & Fielding RA (2009) Effects of chronic overload on muscle hypertrophy and mTOR signaling in young adult and aged rats. Journals of Gerontology, Series A, 64 (12), pp. 1232-1239.
Abstract: We examined the effect of 28 days of overload on mammalian target of rapamycin (mTOR) and extracellular signal-regulated kinase (ERK) signaling in young adult (Y; 6-month old) and aged (O; 30-month old) Fischer 344 × Brown Norway rats subjected to bilateral synergist ablation (SA) of two thirds of the gastrocnemius muscle or sham surgery (CON). Although plantaris (PLA) muscle hypertrophy was attenuated by aging, mTOR phosphorylation was 44% and 35% greater in Y SA and O SA compared with CON (p = .038). Ribosomal protein S6 phosphorylation was 114% and 24% higher in Y SA and O SA compared with CON (p = .009). Eukaryotic initiation factor 2Bϵ phosphorylation was 33% and 9% higher in Y SA and O SA compared with CON (p = .04). Translational signaling in young adult and aged plantaris muscle is equally responsive to chronic overload.
DOI Link: 10.1093/gerona/glp146
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