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Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/22615
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dc.contributor.authorChale-Rush, Angelaen_UK
dc.contributor.authorMorris, Evan Pen_UK
dc.contributor.authorKendall, Tracee Len_UK
dc.contributor.authorBrooks, Naomien_UK
dc.contributor.authorFielding, Roger Aen_UK
dc.date.accessioned2016-08-31T21:57:35Z-
dc.date.available2016-08-31T21:57:35Zen_UK
dc.date.issued2009-12en_UK
dc.identifier.urihttp://hdl.handle.net/1893/22615-
dc.description.abstractWe examined the effect of 28 days of overload on mammalian target of rapamycin (mTOR) and extracellular signal-regulated kinase (ERK) signaling in young adult (Y; 6-month old) and aged (O; 30-month old) Fischer 344 × Brown Norway rats subjected to bilateral synergist ablation (SA) of two thirds of the gastrocnemius muscle or sham surgery (CON). Although plantaris (PLA) muscle hypertrophy was attenuated by aging, mTOR phosphorylation was 44% and 35% greater in Y SA and O SA compared with CON (p = .038). Ribosomal protein S6 phosphorylation was 114% and 24% higher in Y SA and O SA compared with CON (p = .009). Eukaryotic initiation factor 2Bϵ phosphorylation was 33% and 9% higher in Y SA and O SA compared with CON (p = .04). Translational signaling in young adult and aged plantaris muscle is equally responsive to chronic overload.en_UK
dc.language.isoenen_UK
dc.publisherOxford University Pressen_UK
dc.relationChale-Rush A, Morris EP, Kendall TL, Brooks N & Fielding RA (2009) Effects of chronic overload on muscle hypertrophy and mTOR signaling in young adult and aged rats. Journals of Gerontology, Series A, 64 (12), pp. 1232-1239. https://doi.org/10.1093/gerona/glp146en_UK
dc.rightsThe publisher does not allow this work to be made publicly available in this Repository. Please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study.en_UK
dc.rights.urihttp://www.rioxx.net/licenses/under-embargo-all-rights-reserveden_UK
dc.subjectmTORen_UK
dc.subjectMuscle hypertrophyen_UK
dc.subjectMuscle overloaden_UK
dc.subjectAgingen_UK
dc.titleEffects of chronic overload on muscle hypertrophy and mTOR signaling in young adult and aged ratsen_UK
dc.typeJournal Articleen_UK
dc.rights.embargodate2999-12-07en_UK
dc.rights.embargoreason[Chale-Rush et al. J Gerontol 2009.pdf] The publisher does not allow this work to be made publicly available in this Repository therefore there is an embargo on the full text of the work.en_UK
dc.identifier.doi10.1093/gerona/glp146en_UK
dc.identifier.pmid19808838en_UK
dc.citation.jtitleJournals of Gerontology, Series Aen_UK
dc.citation.issn1758-535Xen_UK
dc.citation.issn1079-5006en_UK
dc.citation.volume64en_UK
dc.citation.issue12en_UK
dc.citation.spage1232en_UK
dc.citation.epage1239en_UK
dc.citation.publicationstatusPublisheden_UK
dc.citation.peerreviewedRefereeden_UK
dc.type.statusVoR - Version of Recorden_UK
dc.author.emailn.e.brooks@stir.ac.uken_UK
dc.citation.date06/10/2009en_UK
dc.contributor.affiliationTufts Universityen_UK
dc.contributor.affiliationTufts Universityen_UK
dc.contributor.affiliationTufts Universityen_UK
dc.contributor.affiliationSporten_UK
dc.contributor.affiliationTufts Universityen_UK
dc.identifier.isiWOS:000271573600004en_UK
dc.identifier.scopusid2-s2.0-75949109893en_UK
dc.identifier.wtid751525en_UK
dc.contributor.orcid0000-0002-0269-3475en_UK
dc.date.accepted2009-09-04en_UK
dcterms.dateAccepted2009-09-04en_UK
dc.date.filedepositdate2015-12-17en_UK
rioxxterms.typeJournal Article/Reviewen_UK
rioxxterms.versionVoRen_UK
local.rioxx.authorChale-Rush, Angela|en_UK
local.rioxx.authorMorris, Evan P|en_UK
local.rioxx.authorKendall, Tracee L|en_UK
local.rioxx.authorBrooks, Naomi|0000-0002-0269-3475en_UK
local.rioxx.authorFielding, Roger A|en_UK
local.rioxx.projectInternal Project|University of Stirling|https://isni.org/isni/0000000122484331en_UK
local.rioxx.freetoreaddate2999-12-07en_UK
local.rioxx.licencehttp://www.rioxx.net/licenses/under-embargo-all-rights-reserved||en_UK
local.rioxx.filenameChale-Rush et al. J Gerontol 2009.pdfen_UK
local.rioxx.filecount1en_UK
local.rioxx.source1079-5006en_UK
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