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Appears in Collections:Faculty of Health Sciences and Sport Journal Articles
Peer Review Status: Refereed
Title: Transcranial magnetic stimulation for schizophrenia
Author(s): Dougall, Nadine
Maayan, Nicola
Soares-Weiser, Karla
McDermott, Lisa M
McIntosh, Andrew M
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Keywords: schizophrenia
transcranial magnetic stimulation
auditory hallucinations
Issue Date: Nov-2015
Date Deposited: 17-Nov-2015
Citation: Dougall N, Maayan N, Soares-Weiser K, McDermott LM & McIntosh AM (2015) Transcranial magnetic stimulation for schizophrenia. Schizophrenia Bulletin, 41 (6), pp. 1220-1222.
Abstract: People with schizophrenia typically experience auditory hallucinations or delusions during acute episodes. Although effective drug treatments are available, many have intractable symptoms that do not recover between acute episodes. One proposed alternative to drug treatments is transcranial magnetic stimulation (TMS). To date, many research trials to assess effectiveness of TMS for people with symptoms of schizophrenia have been conducted worldwide. However, there is a lack of consensus on whether TMS should be recommended to be adopted in routine clinical practice. We conducted a systematic review of the literature for all relevant randomized controlled trials (RCTs) comparing TMS with sham or standard treatment. Forty-one trials (1473 participants) survived eligibility criteria and had extractable data. We found significant differences in favor of temporoparietal TMS compared with sham TMS for global state (7 RCTs, n = 224, MD: -0.5, 95% CI: -0.76 to -0.23) and for positive symptoms measured on the Positive and Negative Syndrome Scale (5 RCTs, n = 127, MD: -6.09, 95% CI: -10.95 to -1.22). However, we also found that the quality of trial reporting was frequently suboptimal and the risks of bias were strong or unascertainable for many trial aspects; this led to many results being graded as very low-quality evidence. On that basis, we were unable to definitively support or refute the routine use of TMS in clinical practice. Future definitive trials of TMS with rigorous processes and high-quality reporting are needed.
DOI Link: 10.1093/schbul/sbv121
Rights: This item has been embargoed for a period. During the embargo please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study. This is a pre-copy-editing, author-produced PDF of an article accepted for publication in Schizophrenia Bulletin following peer review. The definitive publisher-authenticated version Nadine Dougall, Nicola Maayan, Karla Soares-Weiser, Lisa M. McDermott and Andrew McIntosh, Transcranial Magnetic Stimulation for Schizophrenia, Schizophr Bull (2015) 41 (6): 1220-1222. is available online at:

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