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dc.contributor.authorDougall, Nadineen_UK
dc.contributor.authorMaayan, Nicolaen_UK
dc.contributor.authorSoares-Weiser, Karlaen_UK
dc.contributor.authorMcDermott, Lisa Men_UK
dc.contributor.authorMcIntosh, Andrew Men_UK
dc.description.abstractPeople with schizophrenia typically experience auditory hallucinations or delusions during acute episodes. Although effective drug treatments are available, many have intractable symptoms that do not recover between acute episodes. One proposed alternative to drug treatments is transcranial magnetic stimulation (TMS). To date, many research trials to assess effectiveness of TMS for people with symptoms of schizophrenia have been conducted worldwide. However, there is a lack of consensus on whether TMS should be recommended to be adopted in routine clinical practice. We conducted a systematic review of the literature for all relevant randomized controlled trials (RCTs) comparing TMS with sham or standard treatment. Forty-one trials (1473 participants) survived eligibility criteria and had extractable data. We found significant differences in favor of temporoparietal TMS compared with sham TMS for global state (7 RCTs, n = 224, MD: -0.5, 95% CI: -0.76 to -0.23) and for positive symptoms measured on the Positive and Negative Syndrome Scale (5 RCTs, n = 127, MD: -6.09, 95% CI: -10.95 to -1.22). However, we also found that the quality of trial reporting was frequently suboptimal and the risks of bias were strong or unascertainable for many trial aspects; this led to many results being graded as very low-quality evidence. On that basis, we were unable to definitively support or refute the routine use of TMS in clinical practice. Future definitive trials of TMS with rigorous processes and high-quality reporting are needed.en_UK
dc.publisherOxford University Pressen_UK
dc.relationDougall N, Maayan N, Soares-Weiser K, McDermott LM & McIntosh AM (2015) Transcranial magnetic stimulation for schizophrenia. Schizophrenia Bulletin, 41 (6), pp. 1220-1222.
dc.rightsThis item has been embargoed for a period. During the embargo please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study. This is a pre-copy-editing, author-produced PDF of an article accepted for publication in Schizophrenia Bulletin following peer review. The definitive publisher-authenticated version Nadine Dougall, Nicola Maayan, Karla Soares-Weiser, Lisa M. McDermott and Andrew McIntosh, Transcranial Magnetic Stimulation for Schizophrenia, Schizophr Bull (2015) 41 (6): 1220-1222. is available online at:
dc.subjecttranscranial magnetic stimulationen_UK
dc.subjectauditory hallucinationsen_UK
dc.titleTranscranial magnetic stimulation for schizophreniaen_UK
dc.typeJournal Articleen_UK
dc.rights.embargoreason[TMS for schizophrenia post print version.pdf] Publisher requires embargo of 12 months after formal publication.en_UK
dc.citation.jtitleSchizophrenia Bulletinen_UK
dc.type.statusAM - Accepted Manuscripten_UK
dc.contributor.affiliationEnhance Reviews Ltden_UK
dc.contributor.affiliationEnhance Reviews Ltden_UK
dc.contributor.affiliationKing's College Londonen_UK
dc.contributor.affiliationUniversity of Edinburghen_UK
rioxxterms.apcnot requireden_UK
rioxxterms.typeJournal Article/Reviewen_UK
local.rioxx.authorDougall, Nadine|0000-0003-3462-6960en_UK
local.rioxx.authorMaayan, Nicola|en_UK
local.rioxx.authorSoares-Weiser, Karla|en_UK
local.rioxx.authorMcDermott, Lisa M|en_UK
local.rioxx.authorMcIntosh, Andrew M|en_UK
local.rioxx.projectInternal Project|University of Stirling|
local.rioxx.filenameTMS for schizophrenia post print version.pdfen_UK
Appears in Collections:Faculty of Health Sciences and Sport Journal Articles

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