|Appears in Collections:||Psychology Journal Articles|
|Peer Review Status:||Refereed|
|Title:||The Postsubiculum and Spatial Learning: The Role of Postsubicular Synaptic Activity and Synaptic Plasticity in Hippocampal Place Cell, Object, and Object-Location Memory|
Stevenson, Cassie H
Shires, Kate L
Smith, Matthew T
Martin, Steven J
Wood, Emma R
|Citation:||Bett D, Stevenson CH, Shires KL, Smith MT, Martin SJ, Dudchenko P & Wood ER (2013) The Postsubiculum and Spatial Learning: The Role of Postsubicular Synaptic Activity and Synaptic Plasticity in Hippocampal Place Cell, Object, and Object-Location Memory. Journal of Neuroscience, 33 (16), pp. 6928-6943. https://doi.org/10.1523/JNEUROSCI.5476-12.2013|
|Abstract:||Visual landmarks exert stimulus control over spatial behavior and the spatially tuned firing of place, head-direction, and grid cells in the rodent. However, the neural site of convergence for representations of landmarks and representations of space has yet to be identified. A potential site of plasticity underlying associations with landmarks is the postsubiculum. To test this, we blocked glutamatergic transmission in the rat postsubiculum with CNQX, or NMDA receptor-dependent plasticity with d-AP5. These infusions were sufficient to block evoked potentials from the lateral dorsal thalamus and long-term depression following tetanization of this input to the postsubiculum, respectively. In a second experiment, CNQX disrupted the stability of rat hippocampal place cell fields in a familiar environment. In a novel environment, blockade of plasticity with d-AP5 in the postsubiculum did not block the formation of a stable place field map following a 6 h delay. In a final behavioral experiment, postsubicular infusions of both compounds blocked object-location memory in the rat, but did not affect object recognition memory. These results suggest that the postsubiculum is necessary for the recognition of familiar environments, and that NMDA receptor-dependent plasticity in the postsubiculum is required for the formation of new object-place associations that support recognition memory. However, plasticity in the postsubiculum is not necessary for the formation of new spatial maps.|
|Rights:||Publisher policy allows this work to be made available in this repository. Published in Journal of Neuroscience, 2013, 33 (16), pp. 6928-6943 by Society for Neuroscience. The original publication is available at: http://www.jneurosci.org/content/33/16/6928|
|Bett et al_Journal of Neuroscience_2013.full.pdf||Fulltext - Published Version||2.92 MB||Adobe PDF||View/Open|
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