Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/22290
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dc.contributor.authorSilva, Sandro P-
dc.contributor.authorDilcher, Meik-
dc.contributor.authorWeber, Franziska-
dc.contributor.authorHufert, Frank T-
dc.contributor.authorWeidmann, Manfred-
dc.contributor.authorCardoso, Jedson F-
dc.contributor.authorCarvalho, Valeria L-
dc.contributor.authorChang, Jannifer O-
dc.contributor.authorMartins, Livia C-
dc.contributor.authorLima, Clayton P S-
dc.contributor.authorSilva, Daisy E A-
dc.contributor.authorVianez-Junior, Joao L S G-
dc.contributor.authorPopov, Vsevolod L-
dc.contributor.authorTravassos, da Rosa Amelia P A-
dc.contributor.authorTesh, Robert B-
dc.contributor.authorVasconcelos, Pedro F C-
dc.contributor.authorNunes, Marcio R T-
dc.date.accessioned2015-10-02T23:12:55Z-
dc.date.issued2014-10-
dc.identifier.urihttp://hdl.handle.net/1893/22290-
dc.description.abstractThe Orbivirus genus of the family Reoviridae is comprised of 22 virus species including the Changuinola virus (CGLV) serogroup. The complete genome sequences of 13 CGLV serotypes isolated between 1961 and 1988 from distinct geographic areas of the Brazilian Amazon region were obtained. All viral sequences were obtained from single-passaged CGLV strains grown in Vero cells. CGLVs are the only orbiviruses known to be transmitted by phlebotomine sandflies. Ultrastructure and molecular analyses by electron microscopy and gel electrophoresis, respectively revealed viral particles with typical orbivirus size and morphology, as well as the presence of a segmented genome with 10 segments. Full-length nucleotide sequencing of each of the ten RNA segments of the 13 CGLV serotypes provided basic information regarding the genome organization, encoded proteins and genetic traits. Segment 2 (encoding VP2) of the CGLV is uncommonly larger in comparison to those found in other orbiviruses and shows varying sizes even among different CGLV serotypes. Phylogenetic analyses support previous serologic findings, which indicated that CGLV constitutes a separate serogroup within the genus Orbivirus. In addition, 6 out of 13 analyzed CGLV serotypes show reassortment of their genome segments.en_UK
dc.language.isoen-
dc.publisherSociety for General Microbiology-
dc.relationSilva SP, Dilcher M, Weber F, Hufert FT, Weidmann M, Cardoso JF, Carvalho VL, Chang JO, Martins LC, Lima CPS, Silva DEA, Vianez-Junior JLGS, Popov VL, Travassos da Rosa APA, Tesh RB, Vasconcelos PFC & Nunes MRT (2014) Genetic and biological characterization of selected Changuinola viruses (Reoviridae, Orbivirus) from Brazil, Journal of General Virology, 95 (10), pp. 2251-2259.-
dc.rightsThe publisher does not allow this work to be made publicly available in this Repository. Please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study.-
dc.subjectArbovirusesen_UK
dc.subjectChanguinola virusen_UK
dc.subjectOrbivirusen_UK
dc.subjectreoviridaeen_UK
dc.titleGenetic and biological characterization of selected Changuinola viruses (Reoviridae, Orbivirus) from Brazilen_UK
dc.typeJournal Articleen_UK
dc.rights.embargodate2999-12-31T00:00:00Z-
dc.rights.embargoreasonThe publisher does not allow this work to be made publicly available in this Repository therefore there is an embargo on the full text of the work.-
dc.identifier.doihttp://dx.doi.org/10.1099/vir.0.064691-0-
dc.identifier.pmid24986085-
dc.citation.jtitleJournal of General Virology-
dc.citation.issn0022-1317-
dc.citation.volume95-
dc.citation.issue10-
dc.citation.spage2251-
dc.citation.epage2259-
dc.citation.publicationstatusPublished-
dc.citation.peerreviewedRefereed-
dc.type.statusPublisher version (final published refereed version)-
dc.author.emailm.w.weidmann@stir.ac.uk-
dc.contributor.affiliationEvandro Chagas Institute-
dc.contributor.affiliationUniversity of Gottingen, Georg-August University-
dc.contributor.affiliationUniversity of Gottingen, Georg-August University-
dc.contributor.affiliationUniversity of Gottingen, Georg-August University-
dc.contributor.affiliationAquaculture-
dc.contributor.affiliationEvandro Chagas Institute-
dc.contributor.affiliationEvandro Chagas Institute-
dc.contributor.affiliationEvandro Chagas Institute-
dc.contributor.affiliationEvandro Chagas Institute-
dc.contributor.affiliationEvandro Chagas Institute-
dc.contributor.affiliationEvandro Chagas Institute-
dc.contributor.affiliationEvandro Chagas Institute-
dc.contributor.affiliationUniversity of Texas Medical Branch-
dc.contributor.affiliationUniversity of Texas Medical Branch-
dc.contributor.affiliationUniversity of Texas Medical Branch-
dc.contributor.affiliationEvandro Chagas Institute-
dc.contributor.affiliationEvandro Chagas Institute-
dc.rights.embargoterms2999-12-31-
dc.rights.embargoliftdate2999-12-31-
dc.identifier.isi000344911900016-
Appears in Collections:Aquaculture Journal Articles

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