Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/22255
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dc.contributor.authorRoy, Priti Kumar-
dc.contributor.authorChowdhury, Sonia-
dc.contributor.authorChatterjee, Amar Nath-
dc.contributor.authorChattopadhyay, Joydev-
dc.contributor.authorNorman, Rachel-
dc.date.accessioned2015-09-29T23:18:22Z-
dc.date.issued2013-09-
dc.identifier.other1350019-
dc.identifier.urihttp://hdl.handle.net/1893/22255-
dc.description.abstractBonhoeffer et al.1 studied the long-term dynamics of HIV drug therapy and virus load dynamics. It is well known that highly active anti retroviral therapy (HAART) can effectively control the HIV replication. It is also well known that reverse transcriptase inhibitors (RTIs) could block new infection and as a result control HIV infection. The positive feedback control on such dynamics plays an important role and CD4+T cells are not only produced from a source but also produced from existing T cells. The present investigation takes into account these factors in the original model of Bonhoeffer et al. The optimal control therapy and the effect of time delay in the positive feedback control function have been investigated. Numerical simulation of the nonlinear model has confirmed our analytical studies.Read More: http://www.worldscientific.com/doi/abs/10.1142/S0218339013500198en_UK
dc.language.isoen-
dc.publisherWorld Scientific-
dc.relationRoy PK, Chowdhury S, Chatterjee AN, Chattopadhyay J & Norman R (2013) A mathematical model on CTL mediated control of hiv infection in a long-term drug therapy, Journal of Biological Systems, 21 (3), Art. No.: 1350019.-
dc.rightsThe publisher does not allow this work to be made publicly available in this Repository. Please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study.-
dc.subjectFeedback Controlen_UK
dc.subjectAsymptotic Stabilityen_UK
dc.subjectCD4+T Cellsen_UK
dc.subjectCTLen_UK
dc.subjectHAARTen_UK
dc.subjectHIVen_UK
dc.subjectT Cell Proliferationen_UK
dc.subjectOptimal Controlen_UK
dc.subjectDelayen_UK
dc.titleA mathematical model on CTL mediated control of hiv infection in a long-term drug therapyen_UK
dc.typeJournal Articleen_UK
dc.rights.embargodate2999-12-31T00:00:00Z-
dc.rights.embargoreasonThe publisher does not allow this work to be made publicly available in this Repository therefore there is an embargo on the full text of the work.-
dc.identifier.doihttp://dx.doi.org/10.1142/S0218339013500198-
dc.citation.jtitleJournal of Biological Systems-
dc.citation.issn0218-3390-
dc.citation.volume21-
dc.citation.issue3-
dc.citation.publicationstatusPublished-
dc.citation.peerreviewedRefereed-
dc.type.statusPublisher version (final published refereed version)-
dc.author.emailr.a.norman@stir.ac.uk-
dc.contributor.affiliationJadavpur University-
dc.contributor.affiliationJadavpur University-
dc.contributor.affiliationJadavpur University-
dc.contributor.affiliationIndian Statistical Institute-
dc.contributor.affiliationComplex Systems-
dc.rights.embargoterms2999-12-31-
dc.rights.embargoliftdate2999-12-31-
dc.identifier.isi000324744900004-
Appears in Collections:Computing Science and Mathematics Journal Articles

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