Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/22129
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dc.contributor.authorGrieves, Rodericken_UK
dc.contributor.authorJenkins, Bryan Wen_UK
dc.contributor.authorHarland, Bruceen_UK
dc.contributor.authorWood, Emma Ren_UK
dc.contributor.authorDudchenko, Paulen_UK
dc.date.accessioned2016-02-27T00:17:40Z-
dc.date.available2016-02-27T00:17:40Z-
dc.date.issued2016-01en_UK
dc.identifier.urihttp://hdl.handle.net/1893/22129-
dc.description.abstractRecent studies have shown that place cells in the hippocampus possess firing fields that repeat in physically similar, parallel environments. These results imply that it should be difficult for animals to distinguish parallel environments at a behavioral level. To test this, we trained rats on a novel odor-location task in an environment with four parallel compartments which had previously been shown to yield place field repetition. A second group of animals was trained on the same task, but with the compartments arranged in different directions, an arrangement we hypothesised would yield less place field repetition. Learning of the odor-location task in the parallel compartments was significantly impaired relative to learning in the radially arranged compartments. Fewer animals acquired the full discrimination in the parallel compartments compared to those trained in the radial compartments, and the former also required many more sessions to reach criterion compared to the latter. To confirm that the arrangement of compartments yielded differences in place cell repetition, in a separate group of animals we recorded from CA1 place cells in both environments. We found that CA1 place cells exhibited repeated fields across four parallel local compartments, but did not do so when the same compartments were arranged radially. To confirm that the differences in place field repetition across the parallel and radial compartments depended on their angular arrangement, and not incidental differences in access to an extra-maze visual landmark, we repeated the recordings in a second set of rats in the absence of the orientation landmark. We found, once again, that place fields showed repetition in parallel compartments, and did not do so in radially arranged compartments. Thus place field repetition, or lack thereof, in these compartments was not dependent on extra-maze cues. Together, these results imply that place field repetition constrains spatial learning. © 2015 Wiley Periodicals, Inc.en_UK
dc.language.isoenen_UK
dc.publisherWiley-Blackwellen_UK
dc.relationGrieves R, Jenkins BW, Harland B, Wood ER & Dudchenko P (2016) Place field repetition and spatial learning in a multicompartment environment. Hippocampus, 26 (1), pp. 118-134. https://doi.org/10.1002/hipo.22496en_UK
dc.rightsThis article is open-access. Open access publishing allows free access to and distribution of published articles where the author retains copyright of their work by employing a Creative Commons attribution licence. Proper attribution of authorship and correct citation details should be givenen_UK
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_UK
dc.subjectspatial cognitionen_UK
dc.subjectplace cellen_UK
dc.subjecthippocampusen_UK
dc.subjectodor discriminationen_UK
dc.subjectcontext discriminationen_UK
dc.titlePlace field repetition and spatial learning in a multicompartment environmenten_UK
dc.typeJournal Articleen_UK
dc.identifier.doi10.1002/hipo.22496en_UK
dc.identifier.pmid26190393en_UK
dc.citation.jtitleHippocampusen_UK
dc.citation.issn1098-1063en_UK
dc.citation.issn1050-9631en_UK
dc.citation.volume26en_UK
dc.citation.issue1en_UK
dc.citation.spage118en_UK
dc.citation.epage134en_UK
dc.citation.publicationstatusPublisheden_UK
dc.citation.peerreviewedRefereeden_UK
dc.type.statusVoR - Version of Recorden_UK
dc.contributor.funderBiotechnology and Biological Sciences Research Councilen_UK
dc.author.emailp.a.dudchenko@stir.ac.uken_UK
dc.citation.date11/08/2015en_UK
dc.contributor.affiliationPsychologyen_UK
dc.contributor.affiliationUniversity of Edinburghen_UK
dc.contributor.affiliationPsychologyen_UK
dc.contributor.affiliationUniversity of Edinburghen_UK
dc.contributor.affiliationPsychologyen_UK
dc.identifier.isiWOS:000369158200012en_UK
dc.identifier.scopusid2-s2.0-84954327527en_UK
dc.identifier.wtid592140en_UK
dc.contributor.orcid0000-0002-1531-5713en_UK
dc.date.accepted2015-07-14en_UK
dcterms.dateAccepted2015-07-14en_UK
dc.date.filedepositdate2015-08-19en_UK
dc.relation.funderprojectLandmark processing in the mammalian brain: do head direction cells drive grid cells and spatial behaviour?en_UK
dc.relation.funderrefBB/L000040/1en_UK
rioxxterms.apcpaiden_UK
rioxxterms.typeJournal Article/Reviewen_UK
rioxxterms.versionVoRen_UK
local.rioxx.authorGrieves, Roderick|en_UK
local.rioxx.authorJenkins, Bryan W|en_UK
local.rioxx.authorHarland, Bruce|en_UK
local.rioxx.authorWood, Emma R|en_UK
local.rioxx.authorDudchenko, Paul|0000-0002-1531-5713en_UK
local.rioxx.projectBB/L000040/1|Biotechnology and Biological Sciences Research Council|http://dx.doi.org/10.13039/501100000268en_UK
local.rioxx.freetoreaddate2015-08-19en_UK
local.rioxx.licencehttp://creativecommons.org/licenses/by/4.0/|2015-08-19|en_UK
local.rioxx.filenameGrieves_et_al-2015-Hippocampus.pdfen_UK
local.rioxx.filecount1en_UK
local.rioxx.source1050-9631en_UK
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