|Appears in Collections:||Computing Science and Mathematics Conference Papers and Proceedings|
|Peer Review Status:||Refereed|
|Title:||Using process algebra to model radiation induced bystander effects|
|Citation:||Lintott R, McMahon S, Prise K, Addie-Lagorio C & Shankland C (2014) Using process algebra to model radiation induced bystander effects. In: Mendes P, Dada J & Smallbone K (eds.) Computational Methods in Systems Biology: 12th International Conference, CMSB 2014, Manchester, UK, November 17-19, 2014, Proceedings. Lecture Notes in Computer Science, 8859. Computational Methods in Systems Biology 2014, Manchester, UK, 17.11.2014-19.11.2014. Cham, Switzerland: Springer International Publishing, pp. 196-210. http://link.springer.com/chapter/10.1007/978-3-319-12982-2_14; https://doi.org/10.1007/978-3-319-12982-2_14|
|Series/Report no.:||Lecture Notes in Computer Science, 8859|
|Conference Name:||Computational Methods in Systems Biology 2014|
|Conference Dates:||2014-11-17 - 2014-11-19|
|Conference Location:||Manchester, UK|
|Abstract:||Radiation induced bystander effects are secondary effects caused by the production of chemical signals by cells in response to radiation. We present a Bio-PEPA model which builds on previous modelling work in this field to predict: the surviving fraction of cells in response to radiation, the relative proportion of cell death caused by bystander signalling, the risk of non-lethal damage and the probability of observing bystander signalling for a given dose. This work provides the foundation for modelling bystander effects caused by biologically realistic dose distributions, with implications for cancer therapies.|
|Status:||AM - Accepted Manuscript|
|Rights:||Publisher policy allows this work to be made available in this repository; The final publication is available at Springer via http://dx.doi.org/10.1007/978-3-319-12982-2_14|
|CSMBpaper.pdf||Fulltext - Accepted Version||305.81 kB||Adobe PDF||View/Open|
This item is protected by original copyright
Items in the Repository are protected by copyright, with all rights reserved, unless otherwise indicated.
If you believe that any material held in STORRE infringes copyright, please contact email@example.com providing details and we will remove the Work from public display in STORRE and investigate your claim.