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dc.contributor.authorO'Carroll, Ronanen_UK
dc.contributor.authorChambers, Julieen_UK
dc.contributor.authorBrownlee, Lindaen_UK
dc.contributor.authorLibby, Gillianen_UK
dc.contributor.authorSteele, Roberten_UK
dc.description.abstractObjective. Screening is key to early detection of colorectal cancer. Our aim was to determine whether a simple anticipated regret (AR) intervention could increase colorectal cancer screening uptake. Methods. We conducted a randomised controlled trial of a simple, questionnaire-based AR intervention, delivered alongside existing pre-notification letters. 60,000 adults aged 50-74 from the Scottish National Screening programme were randomised to: 1) no questionnaire (control), 2) Health Locus of Control questionnaire (HLOC) or 3) HLOC plus anticipated regret questionnaire (AR). Primary outcome was guaiac Faecal Occult Blood Test (FOBT) return. Secondary outcomes included intention to return test kit and perceived disgust (ICK). Results. 59,366 people were analysed as allocated (Intentionto- treat (ITT)); there were no overall differences between treatment groups on FOBT uptake (control: 57.3%, HLOC: 56.9%, AR: 57.4%). 13,645 (34.2%) people returned questionnaires. Analysis of the secondary questionnaire measures showed that AR had an indirect effect on FOBT uptake via intention, whilst ICK had a direct effect on FOBT uptake over and above intention. The effect of AR on FOBT uptake was also moderated by intention strength: for less than strong intenders only, uptake was 4.2% higher in the AR (84.6%) versus the HLOC group (80.4%) (95% CI for difference (2.0, 6.5)). Conclusion. The findings show that psychological concepts including anticipated regret and perceived disgust (ICK) are important factors in determining FOBT uptake. However, there was no simple effect of the AR intervention in the ITT. We conclude that exposure to AR in those with low intentions may be required to increase FOBT uptake. Current controlled trials: www.controlledtrials. com number: ISRCTN74986452.en_UK
dc.relationO'Carroll R, Chambers J, Brownlee L, Libby G & Steele R (2015) Anticipated regret to increase uptake of colorectal cancer screening (ARTICS): a randomised controlled trial. Social Science and Medicine, 142, pp. 118-127.
dc.rightsThis article is open-access under a CC BY-NC_ND licence. Open access publishing allows free access to and distribution of published articles where the author retains copyright of their work by employing a Creative Commons attribution licence — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use. You may not use the material for commercial purposes. If you remix, transform, or build upon the material, you may not distribute the modified material. You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.en_UK
dc.subjectColorectal canceren_UK
dc.subjectAnticipated Regreten_UK
dc.subjectFaecal Occult Blood Testen_UK
dc.titleAnticipated regret to increase uptake of colorectal cancer screening (ARTICS): a randomised controlled trialen_UK
dc.typeJournal Articleen_UK
dc.citation.jtitleSocial Science and Medicineen_UK
dc.type.statusVoR - Version of Recorden_UK
dc.contributor.funderChief Scientist Officeen_UK
dc.contributor.affiliationScottish Bowel Screening Centreen_UK
dc.contributor.affiliationScottish Bowel Screening Centreen_UK
dc.contributor.affiliationUniversity of Dundeeen_UK
dc.relation.funderprojectA randomised controlled trial of a brief psychological intervention to increase the uptake of colorectal cancer screening in Scotlanden_UK
rioxxterms.typeJournal Article/Reviewen_UK
local.rioxx.authorO'Carroll, Ronan|0000-0002-5130-291Xen_UK
local.rioxx.authorChambers, Julie|en_UK
local.rioxx.authorBrownlee, Linda|en_UK
local.rioxx.authorLibby, Gillian|en_UK
local.rioxx.authorSteele, Robert|en_UK
local.rioxx.projectCZH/4/793|Chief Scientist Office|
local.rioxx.filenameO'Carroll et al_SSM_2015.pdfen_UK
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