Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/21993
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dc.contributor.authorBetancor, Monicaen_UK
dc.contributor.authorAlmaida, Pedroen_UK
dc.contributor.authorSprague, Matthewen_UK
dc.contributor.authorHernandez, Aen_UK
dc.contributor.authorTocher, Douglas Ren_UK
dc.date.accessioned2018-04-11T00:34:17Z-
dc.date.available2018-04-11T00:34:17Z-
dc.date.issued2015-06en_UK
dc.identifier.urihttp://hdl.handle.net/1893/21993-
dc.description.abstractMitochondrial decay is generally associated with impairment in the organelle bioenergetics function and increased oxidative stress, and it appears that deterioration of mitochondrial inner membrane phospholipids (PL) and accumulation of mitochondrial DNA (mtDNA) mutations are among the main mechanisms involved in this process. In the present study, mitochondrial membrane PL compositions, oxidative status (TBARS content and SOD activity) and mtDNA gene expression of muscle and liver were analyzed in zebrafish fed two diets with lipid supplied either by rapeseed oil (RO) or a blend 60:40 of RO and DHA500 TG oil (DHA). Two feeding trials were performed using zebrafish from the same population of two ages (8- and 21-months). Dietary FA composition affected fish growth in 8-month-old animals, which could be related with an increase in stress promoted by diet composition. Lipid peroxidation was considerably higher in mitochondria of 8-month-old zebrafish fed the DHA diet than in animals fed the RO diet. This could indicate higher oxidative damage to mitochondrial lipids, very likely due to increased incorporation of DHA in PL of mitochondrial membranes. Lipids would be among the first molecules affected by mitochondrial reactive oxygen species, and lipid peroxidation could propagate oxidative reactions that would damage other molecules, including mtDNA. Mitochondrial lipid peroxidation and gene expression of 21-month-old fish showed lower responsiveness to diet composition than those of younger fish. Differences found in the effect of diet composition on mitochondrial lipids between the two age groups could be indicating age-related changes in the ability to maintain structural homeostasis of mitochondrial membranes.en_UK
dc.language.isoenen_UK
dc.publisherSpringeren_UK
dc.relationBetancor M, Almaida P, Sprague M, Hernandez A & Tocher DR (2015) Roles of selenoprotein antioxidant protection in zebrafish, Danio rerio, subjected to dietary oxidative stress. Fish Physiology and Biochemistry, 41 (3), pp. 705-720. https://doi.org/10.1007/s10695-015-0040-2en_UK
dc.rightsThis item has been embargoed for a period. During the embargo please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study. Publisher policy allows this work to be made available in this repository; The final publication is available at Springer via http://dx.doi.org/10.1007/s10695-015-0040-2en_UK
dc.subjectDieten_UK
dc.subjectfatty aciden_UK
dc.subjectmitochondriaen_UK
dc.subjectzebrafishen_UK
dc.subjectoxidative stressen_UK
dc.subjectphospholipid.en_UK
dc.titleRoles of selenoprotein antioxidant protection in zebrafish, Danio rerio, subjected to dietary oxidative stressen_UK
dc.typeJournal Articleen_UK
dc.rights.embargodate2016-06-08en_UK
dc.rights.embargoreason[Effects of dietary fatty acids on mitochondrial .pdf] Publisher requires embargo of 12 months after formal publication.en_UK
dc.identifier.doi10.1007/s10695-015-0040-2en_UK
dc.citation.jtitleFish Physiology and Biochemistryen_UK
dc.citation.issn1573-5168en_UK
dc.citation.issn0920-1742en_UK
dc.citation.volume41en_UK
dc.citation.issue3en_UK
dc.citation.spage705en_UK
dc.citation.epage720en_UK
dc.citation.publicationstatusPublisheden_UK
dc.citation.peerreviewedRefereeden_UK
dc.type.statusAM - Accepted Manuscripten_UK
dc.contributor.funderEuropean Commissionen_UK
dc.author.emaildrt1@stir.ac.uken_UK
dc.citation.date07/03/2015en_UK
dc.contributor.affiliationInstitute of Aquacultureen_UK
dc.contributor.affiliationInstitute of Aquacultureen_UK
dc.contributor.affiliationInstitute of Aquacultureen_UK
dc.contributor.affiliationUniversity of Stirlingen_UK
dc.contributor.affiliationInstitute of Aquacultureen_UK
dc.identifier.isiWOS:000354619300003en_UK
dc.identifier.scopusid2-s2.0-84924263567en_UK
dc.identifier.wtid885811en_UK
dc.contributor.orcid0000-0003-1626-7458en_UK
dc.contributor.orcid0000-0002-0723-2387en_UK
dc.contributor.orcid0000-0002-8603-9410en_UK
dc.date.accepted2015-02-27en_UK
dcterms.dateAccepted2015-02-27en_UK
dc.date.filedepositdate2015-07-08en_UK
dc.relation.funderprojectOxidation, Lipids, DNA and Mitochondriaen_UK
dc.relation.funderrefPIEF-GA-2011-297964en_UK
rioxxterms.apcnot requireden_UK
rioxxterms.typeJournal Article/Reviewen_UK
rioxxterms.versionAMen_UK
local.rioxx.authorBetancor, Monica|0000-0003-1626-7458en_UK
local.rioxx.authorAlmaida, Pedro|en_UK
local.rioxx.authorSprague, Matthew|0000-0002-0723-2387en_UK
local.rioxx.authorHernandez, A|en_UK
local.rioxx.authorTocher, Douglas R|0000-0002-8603-9410en_UK
local.rioxx.projectPIEF-GA-2011-297964|European Commission (Horizon 2020)|en_UK
local.rioxx.freetoreaddate2016-06-08en_UK
local.rioxx.licencehttp://www.rioxx.net/licenses/under-embargo-all-rights-reserved||2016-06-07en_UK
local.rioxx.licencehttp://www.rioxx.net/licenses/all-rights-reserved|2016-06-08|en_UK
local.rioxx.filenameEffects of dietary fatty acids on mitochondrial .pdfen_UK
local.rioxx.filecount1en_UK
local.rioxx.source0920-1742en_UK
Appears in Collections:Aquaculture Journal Articles

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