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dc.contributor.authorSouto, Sandra-
dc.contributor.authorLopez, Jimena Benjamin-
dc.contributor.authorAlonso, Maria del Carmen-
dc.contributor.authorGarcia-Rosado, Esther-
dc.contributor.authorBandin, Isabel-
dc.description.abstractThe susceptibility of juvenile European sea bass and Senegalese sole to three VNNV isolates (a reassortant RGNNV/SJNNV, as well as the parental RGNNV and SJNNV genotypes) has been evaluated by challenges using two inoculation ways (bath and intramuscular injection). The results demonstrate that these two fish species are susceptible to all the VNNV isolates tested. In European sea bass, RGNNV caused the highest cumulative mortality, reaching maximum values of viral RNA and titres. Although the SJNNV isolate did not provoke mortality or clinical signs of disease in this fish species, viral production in survivor fish was determined; on the other hand the reassortant isolate did cause mortality and clinical signs of disease, although less evident than those recorded after RGNNV infection. These results suggest that the changes suffered by the SJNNV RNA2 segment of the reassortant isolate, compared to the parental SJNNV, may have involved host-specificity and/or virulence determinants for European sea bass. Regarding Senegalese sole, although the three isolates caused 100% mortality, the reassortant strain provoked the most acute symptoms, and more quickly, especially in the bath challenge. This was also the isolate showing less difference between the number of RNA copies and viral titre, reaching the highest titres of infective viral particles in nervous tissue of infected animals. The RGNNV isolate produced the lowest values of infective viral particles. All these results suggest that the RGNNV and the reassortant isolates are the most suited for infecting European sea bass and Senegalese sole, respectively.en_UK
dc.relationSouto S, Lopez Jimena B, Alonso MdC, Garcia-Rosado E & Bandin I (2015) Experimental susceptibility of European sea bass and Senegalese sole to different betanodavirus isolates, Veterinary Microbiology, 177 (1-2), pp. 53-61.-
dc.rightsThe publisher does not allow this work to be made publicly available in this Repository. Please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study.-
dc.subjectNatural reassortanten_UK
dc.subjectExperimental infectionen_UK
dc.subjectEuropean sea bassen_UK
dc.subjectSenegalese soleen_UK
dc.titleExperimental susceptibility of European sea bass and Senegalese sole to different betanodavirus isolatesen_UK
dc.typeJournal Articleen_UK
dc.rights.embargoreasonThe publisher does not allow this work to be made publicly available in this Repository therefore there is an embargo on the full text of the work.-
dc.citation.jtitleVeterinary Microbiology-
dc.type.statusPublisher version (final published refereed version)-
dc.contributor.affiliationUniversity of Santiago de Compostela (USC)-
dc.contributor.affiliationUniversity of Malaga-
dc.contributor.affiliationUniversity of Malaga-
dc.contributor.affiliationUniversity of Santiago de Compostela (USC)-
Appears in Collections:Aquaculture Journal Articles

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