Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/21416
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dc.contributor.authorMacKenzie, Simonen_UK
dc.contributor.authorBalasch, Joan Cen_UK
dc.contributor.authorNovoa, Beatrizen_UK
dc.contributor.authorRibas, Laiaen_UK
dc.contributor.authorRoher, Nereaen_UK
dc.contributor.authorKrasnov, Alekseien_UK
dc.contributor.authorFigueras, Antonioen_UK
dc.date.accessioned2015-07-23T08:35:44Z-
dc.date.available2015-07-23T08:35:44Z-
dc.date.issued2008-03-26en_UK
dc.identifier.other141en_UK
dc.identifier.urihttp://hdl.handle.net/1893/21416-
dc.description.abstractBackground: The response of the trout, O. mykiss, head kidney to bacterial lipopolysaccharide (LPS) or active and attenuated infectious hematopoietic necrosis virus (IHNV and attINHV respectively) intraperitoneal challenge, 24 and 72 hours post-injection, was investigated using a salmonid-specific cDNA microarray. Results: The head kidney response to i.p. LPS-induced inflammation in the first instance displays an initial stress reaction involving suppression of major cellular processes, including immune function, followed by a proliferative hematopoietic-type/biogenesis response 3 days after administration. The viral response at the early stage of infection highlights a suppression of hematopoietic and protein biosynthetic function and a stimulation of immune response. In fish infected with IHNV a loss of cellular function including signal transduction, cell cycle and transcriptional activity 72 hours after infection reflects the tissue-specific pathology of IHNV infection. attIHNV treatment on the other hand shows a similar pattern to native IHNV infection at 24 hours however at 72 hours a divergence from the viral response is seen and replace with a recovery response more similar to that observed for LPS is observed. Conclusion: In conclusion we have been able to identify and characterise by transcriptomic analysis two different types of responses to two distinct immune agents, a virus, IHNV and a bacterial cell wall component, LPS and a 'mixed' response to an attenuated IHNV. This type of analysis will lead to a greater understanding of the physiological response and the development of effective immune responses in salmonid fish to different pathogenic and pro-inflammatory agents.en_UK
dc.language.isoenen_UK
dc.publisherBioMed Centralen_UK
dc.relationMacKenzie S, Balasch JC, Novoa B, Ribas L, Roher N, Krasnov A & Figueras A (2008) Comparative analysis of the acute response of the trout, O. mykiss, head kidney to in vivo challenge with virulent and attenuated infectious hematopoietic necrosis virus and LPS-induced inflammation. BMC Genomics, 9, Art. No.: 141. https://doi.org/10.1186/1471-2164-9-141en_UK
dc.rights© 2008 MacKenzie et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.en_UK
dc.rights.urihttp://creativecommons.org/licenses/by/2.0/en_UK
dc.titleComparative analysis of the acute response of the trout, O. mykiss, head kidney to in vivo challenge with virulent and attenuated infectious hematopoietic necrosis virus and LPS-induced inflammationen_UK
dc.typeJournal Articleen_UK
dc.identifier.doi10.1186/1471-2164-9-141en_UK
dc.citation.jtitleBMC Genomicsen_UK
dc.citation.issn1471-2164en_UK
dc.citation.volume9en_UK
dc.citation.publicationstatusPublisheden_UK
dc.citation.peerreviewedRefereeden_UK
dc.type.statusVoR - Version of Recorden_UK
dc.author.emailsimon.mackenzie@stir.ac.uken_UK
dc.contributor.affiliationComplex Systems - LEGACYen_UK
dc.contributor.affiliationUniversitat Autonoma de Barcelonaen_UK
dc.contributor.affiliationSpanish National Research Council (CSIC)en_UK
dc.contributor.affiliationImperial College Londonen_UK
dc.contributor.affiliationUniversitat de Barcelonaen_UK
dc.contributor.affiliationAkvaforsk Genetics Center ASen_UK
dc.contributor.affiliationSpanish National Research Council (CSIC)en_UK
dc.identifier.isiWOS:000254891800001en_UK
dc.identifier.scopusid2-s2.0-42049084672en_UK
dc.identifier.wtid605500en_UK
dc.contributor.orcid0000-0003-1845-6826en_UK
dcterms.dateAccepted2008-03-26en_UK
dc.date.filedepositdate2015-01-29en_UK
rioxxterms.typeJournal Article/Reviewen_UK
rioxxterms.versionVoRen_UK
local.rioxx.authorMacKenzie, Simon|0000-0003-1845-6826en_UK
local.rioxx.authorBalasch, Joan C|en_UK
local.rioxx.authorNovoa, Beatriz|en_UK
local.rioxx.authorRibas, Laia|en_UK
local.rioxx.authorRoher, Nerea|en_UK
local.rioxx.authorKrasnov, Aleksei|en_UK
local.rioxx.authorFigueras, Antonio|en_UK
local.rioxx.projectInternal Project|University of Stirling|https://isni.org/isni/0000000122484331en_UK
local.rioxx.freetoreaddate2015-01-29en_UK
local.rioxx.licencehttp://creativecommons.org/licenses/by/2.0/|2015-01-29|en_UK
local.rioxx.filenameMacKenzie_BMC Genomics 2008.pdfen_UK
local.rioxx.filecount1en_UK
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