Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/21273
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dc.contributor.authorZimmerman, Yvetteen_UK
dc.contributor.authorFoidart, Jean-Michelen_UK
dc.contributor.authorPintiaux, Axelleen_UK
dc.contributor.authorMinon, Jean-Marcen_UK
dc.contributor.authorFauser, Bart C J Men_UK
dc.contributor.authorCobey, Kelly Den_UK
dc.contributor.authorCoelingh Bennink, Herjan J Ten_UK
dc.date.accessioned2016-05-17T01:46:32Z-
dc.date.available2016-05-17T01:46:32Z-
dc.date.issued2015-02en_UK
dc.identifier.urihttp://hdl.handle.net/1893/21273-
dc.description.abstractObjectives: Combined oral contraceptives (COCs) decrease testosterone (T) levels. This study investigated restoration of T and other androgen concentrations during COC use by co-administration of dehydroepiandrosterone (DHEA). Study design: In this randomized, double-blind, placebo-controlled study in 99 new COC starters (18-35 years old with BMI range 18-34 kg/m2), a COC containing 30 μg ethinylestradiol (EE) and 3 mg drospirenone (DRSP) was used for 3 cycles, followed by 6 cycles of the same COC combined with either 50 mg/day DHEA or placebo. Total T, albumin, sex hormone-binding globulin (SHBG), DHEA-sulfate (DHEA-S), Δ4-androstenedione (AD), 3α-androstanediol glucuronide (ADG) and estradiol (E2) were measured, whereas free T and the free T index (FTI) were calculated. Assessments took place at baseline (no COC use), after the run-in period (COC use alone) and during the treatment period (DHEA or placebo). Results: During COC use alone androgen levels decreased, especially total T by 62% and free T by 86%, and SHBG increased by 243%. Total T increased with DHEA compared to placebo (change from end of run-in period to end of treatment period: 1.3 ± 1.2 nmol/L vs 0.0 ± 0.4 nmol/L; P < 0.0001), and was restored to baseline levels. Free T and the FTI increased significantly (P < 0.0001), but the free T level was still 53% below baseline levels. DHEA-S, AD and ADG increased significantly to levels above baseline (P < 0.0001 for each). DHEA had no effect on SHBG, albumin and E2. Conclusions: An EE/DRSP containing COC strongly suppressed endogenous androgen concentrations in all users. The addition of 50 mg DHEA to a COC regimen containing EE/DRSP restored total T to baseline levels, but free T levels were restored by only 47% as most of the T remains bound to SHBG. Implications: When using a COC that increases SHBG considerably, a daily dose of 50 mg DHEA is insufficient to normalize free T levels completely.en_UK
dc.language.isoenen_UK
dc.publisherElsevieren_UK
dc.relationZimmerman Y, Foidart J, Pintiaux A, Minon J, Fauser BCJM, Cobey KD & Coelingh Bennink HJT (2015) Restoring testosterone levels by adding dehydroepiandrosterone to a drospirenone containing combined oral contraceptive: I Endocrine effects. Contraception, 91 (2), pp. 127-133. https://doi.org/10.1016/j.contraception.2014.11.002en_UK
dc.rightsPublished in Contraception by Elsevier; Elsevier believes that individual authors should be able to distribute their AAMs for their personal voluntary needs and interests, e.g. posting to their websites or their institution’s repository, e-mailing to colleagues. However, our policies differ regarding the systematic aggregation or distribution of AAMs to ensure the sustainability of the journals to which AAMs are submitted. Therefore, deposit in, or posting to, subject-oriented or centralized repositories (such as PubMed Central), or institutional repositories with systematic posting mandates is permitted only under specific agreements between Elsevier and the repository, agency or institution, and only consistent with the publisher’s policies concerning such repositories. Voluntary posting of AAMs in the arXiv subject repository is permitted.en_UK
dc.subjectfree testosteroneen_UK
dc.subjectSHBGen_UK
dc.subjectDHEAen_UK
dc.subjectandrogensen_UK
dc.titleRestoring testosterone levels by adding dehydroepiandrosterone to a drospirenone containing combined oral contraceptive: I Endocrine effectsen_UK
dc.typeJournal Articleen_UK
dc.identifier.doi10.1016/j.contraception.2014.11.002en_UK
dc.citation.jtitleContraceptionen_UK
dc.citation.issn0010-7824en_UK
dc.citation.volume91en_UK
dc.citation.issue2en_UK
dc.citation.spage127en_UK
dc.citation.epage133en_UK
dc.citation.publicationstatusPublisheden_UK
dc.citation.peerreviewedRefereeden_UK
dc.type.statusAM - Accepted Manuscripten_UK
dc.author.emailkelly.cobey@stir.ac.uken_UK
dc.citation.date13/11/2014en_UK
dc.contributor.affiliationPantarhei Bioscience BV, The Netherlandsen_UK
dc.contributor.affiliationUniversity Hospital CHR Citadelleen_UK
dc.contributor.affiliationUniversity Hospital CHR Citadelleen_UK
dc.contributor.affiliationUniversity Hospital CHR Citadelleen_UK
dc.contributor.affiliationUtrecht Universityen_UK
dc.contributor.affiliationPsychologyen_UK
dc.contributor.affiliationPantarhei Bioscience BV, The Netherlandsen_UK
dc.identifier.isiWOS:000348896300007en_UK
dc.identifier.scopusid2-s2.0-84921051393en_UK
dc.identifier.wtid611361en_UK
dc.contributor.orcid0000-0003-2797-1686en_UK
dc.date.accepted2014-11-02en_UK
dcterms.dateAccepted2014-11-02en_UK
dc.date.filedepositdate2014-11-25en_UK
rioxxterms.apcnot requireden_UK
rioxxterms.typeJournal Article/Reviewen_UK
rioxxterms.versionAMen_UK
local.rioxx.authorZimmerman, Yvette|en_UK
local.rioxx.authorFoidart, Jean-Michel|en_UK
local.rioxx.authorPintiaux, Axelle|en_UK
local.rioxx.authorMinon, Jean-Marc|en_UK
local.rioxx.authorFauser, Bart C J M|en_UK
local.rioxx.authorCobey, Kelly D|0000-0003-2797-1686en_UK
local.rioxx.authorCoelingh Bennink, Herjan J T|en_UK
local.rioxx.projectInternal Project|University of Stirling|https://isni.org/isni/0000000122484331en_UK
local.rioxx.freetoreaddate2014-11-25en_UK
local.rioxx.licencehttp://www.rioxx.net/licenses/all-rights-reserved|2014-11-25|en_UK
local.rioxx.filenameendocrine.pdfen_UK
local.rioxx.filecount1en_UK
local.rioxx.source0010-7824en_UK
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