Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/21144
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dc.contributor.authorBoltana, Sebastianen_UK
dc.contributor.authorTridico, Rosaen_UK
dc.contributor.authorTeles, Marianaen_UK
dc.contributor.authorMacKenzie, Simonen_UK
dc.contributor.authorTort, Lluisen_UK
dc.date.accessioned2014-10-02T23:38:47Z-
dc.date.available2014-10-02T23:38:47Z-
dc.date.issued2014-08en_UK
dc.identifier.urihttp://hdl.handle.net/1893/21144-
dc.description.abstractIn fish, the defence system recognises pathogenic microorganisms via pathogen recognition receptors (PRRs) that sense particular structures of the pathogens; the so-called pathogen associated molecular patterns (PAMPs) such as bacterial lipopolysaccharides (LPSs). The result of the PAMP-PRR interactions leads to complex and orchestrated immune responses. In this study, Sparus aurata (Gilthead seabream) were intraperitoneally injected with purified lipopolysaccharide (LPS) from Aeromonas salmonicida (As)- and Vibrio anguillarum (Va) (1 mg*Kgfish-1), both Gram negative bacteria responsible for vibriosis and furunculosis respectively, therefore causing an impact upon marine fish cultures. Head-kidney, intestine, spleen, liver and blood samples were collected at 3, 6, 12 and 24 h post-injection. Plasma levels of cortisol, prostaglandins and lactate were measured and were significantly increased after As-LPS and Va-LPS treatment. Furthermore, tissue-specific differences of the gene regulatory patterns were evident for each LPS. When monocyte/macrophage cell cultures were challenged with As-LPS and Va-LPS, the pro-inflammatory cytokine mRNA abundances present a similar pattern of response. However, As-LPS always triggered a stronger response concerning TNFα, IL1β and cyclooxygenase-2 (COX2) mRNA abundance as well as PGE2 levels in the supernatant. Overall, the results indicate that specific LPSs do not activate different pro-inflammatory responses and that the observed gene expression pattern is tissue and concentration dependent.en_UK
dc.language.isoenen_UK
dc.publisherElsevieren_UK
dc.relationBoltana S, Tridico R, Teles M, MacKenzie S & Tort L (2014) Lipopolysaccharides isolated from Aeromonas salmonicida and Vibrio anguillarum show quantitative but not qualitative differences in inflammatory outcome in Sparus aurata (Gilthead seabream). Fish and Shellfish Immunology, 39 (2), pp. 475-482. https://doi.org/10.1016/j.fsi.2014.06.003en_UK
dc.rightsThe publisher does not allow this work to be made publicly available in this Repository. Please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study.en_UK
dc.rights.urihttp://www.rioxx.net/licenses/under-embargo-all-rights-reserveden_UK
dc.subjectLipopolysaccharideen_UK
dc.subjectDefence systemen_UK
dc.subjectSparus aurataen_UK
dc.titleLipopolysaccharides isolated from Aeromonas salmonicida and Vibrio anguillarum show quantitative but not qualitative differences in inflammatory outcome in Sparus aurata (Gilthead seabream)en_UK
dc.typeJournal Articleen_UK
dc.rights.embargodate3000-01-01en_UK
dc.rights.embargoreason[Fish and Shellfish Immunology 2014.pdf] The publisher does not allow this work to be made publicly available in this Repository therefore there is an embargo on the full text of the work.en_UK
dc.identifier.doi10.1016/j.fsi.2014.06.003en_UK
dc.citation.jtitleFish and Shellfish Immunologyen_UK
dc.citation.issn1050-4648en_UK
dc.citation.volume39en_UK
dc.citation.issue2en_UK
dc.citation.spage475en_UK
dc.citation.epage482en_UK
dc.citation.publicationstatusPublisheden_UK
dc.citation.peerreviewedRefereeden_UK
dc.type.statusVoR - Version of Recorden_UK
dc.author.emailsebastian.boltana@stir.ac.uken_UK
dc.contributor.affiliationInstitute of Aquacultureen_UK
dc.contributor.affiliationUniversitat Autonoma de Barcelonaen_UK
dc.contributor.affiliationUniversitat Autonoma de Barcelonaen_UK
dc.contributor.affiliationInstitute of Aquacultureen_UK
dc.contributor.affiliationUniversitat Autonoma de Barcelonaen_UK
dc.identifier.isiWOS:000339773000045en_UK
dc.identifier.scopusid2-s2.0-84903475791en_UK
dc.identifier.wtid619328en_UK
dc.contributor.orcid0000-0003-1845-6826en_UK
dc.date.accepted2014-06-05en_UK
dcterms.dateAccepted2014-06-05en_UK
dc.date.filedepositdate2014-10-02en_UK
rioxxterms.apcnot requireden_UK
rioxxterms.typeJournal Article/Reviewen_UK
rioxxterms.versionVoRen_UK
local.rioxx.authorBoltana, Sebastian|en_UK
local.rioxx.authorTridico, Rosa|en_UK
local.rioxx.authorTeles, Mariana|en_UK
local.rioxx.authorMacKenzie, Simon|0000-0003-1845-6826en_UK
local.rioxx.authorTort, Lluis|en_UK
local.rioxx.projectInternal Project|University of Stirling|https://isni.org/isni/0000000122484331en_UK
local.rioxx.freetoreaddate3000-01-01en_UK
local.rioxx.licencehttp://www.rioxx.net/licenses/under-embargo-all-rights-reserved||en_UK
local.rioxx.filenameFish and Shellfish Immunology 2014.pdfen_UK
local.rioxx.filecount1en_UK
local.rioxx.source1050-4648en_UK
Appears in Collections:Aquaculture Journal Articles

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