|Appears in Collections:
|Biological and Environmental Sciences Book Chapters and Sections
|Small GTP Binding Proteins and the Control of Phagocytic Uptake
|Wiedemann A, Lim J & Caron E (2005) Small GTP Binding Proteins and the Control of Phagocytic Uptake. In: Rosales C (ed.) Molecular Mechanisms of Phagocytosis. Medical Intelligence Unit. New York: Landes Bioscience/Springer Science, pp. 72-84. http://link.springer.com/chapter/10.1007/978-0-387-28669-3_6#
|Medical Intelligence Unit
|Phagocytosis is a conserved cellular process in Eukaryotes. A multi-step process, it involves the recognition of paniculate material, e.g., microbes and apoptotic cells, their F-actin-driven engulfment and the subsequent destruction of the phagocytized material in phagolysosomes. Distinct sets of small GTP-binding proteins (Rap1, Arf6, Rho and Rab proteins) control and coordinate the successive steps of the phagocytic process. Moreover, these proteins are often targeted by microbial virulence factors. This review summarizes and discusses the evidence implicating Ras, Rho, Arf and Rab-family GTPases in the signalling pathways driving particle recognition and uptake.
|The publisher does not allow this work to be made publicly available in this Repository. Please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study.
|2004 Wiedermann et al review phagocytosis GTPases.pdf
|Fulltext - Published Version
|Under Embargo until 3000-12-01 Request a copy
Note: If any of the files in this item are currently embargoed, you can request a copy directly from the author by clicking the padlock icon above. However, this facility is dependent on the depositor still being contactable at their original email address.
This item is protected by original copyright
Items in the Repository are protected by copyright, with all rights reserved, unless otherwise indicated.
The metadata of the records in the Repository are available under the CC0 public domain dedication: No Rights Reserved https://creativecommons.org/publicdomain/zero/1.0/
If you believe that any material held in STORRE infringes copyright, please contact firstname.lastname@example.org providing details and we will remove the Work from public display in STORRE and investigate your claim.