Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/21030
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dc.contributor.authorPandrea, Ivona-
dc.contributor.authorOnanga, Richard-
dc.contributor.authorKornfeld, Christopher-
dc.contributor.authorRouquet, Pierre-
dc.contributor.authorBourry, Olivier-
dc.contributor.authorClifford, Stephen L-
dc.contributor.authorTelfer, Paul T-
dc.contributor.authorAbernethy, Katharine-
dc.contributor.authorWhite, Lee-
dc.contributor.authorNgari, Paul-
dc.contributor.authorMuller-Trutwin, Michaela-
dc.contributor.authorRoques, Pierre-
dc.contributor.authorMarx, Preston A-
dc.contributor.authorSimon, Francois-
dc.contributor.authorApetrei, Cristian-
dc.date.accessioned2014-09-05T00:36:53Z-
dc.date.issued2003-12-05-
dc.identifier.urihttp://hdl.handle.net/1893/21030-
dc.description.abstractViral loads were investigated in SIVmnd-1 chronically infected mandrills and the results were compared with those previously observed in other nonpathogenic natural SIV infections. Four naturally and 11 experimentally SIVmnd-1-infected mandrills from a semi-free-ranging colony were studied during the chronic phase of infection. Four SIVmnd-1-infected wild mandrills were also included for comparison. Twelve uninfected mandrills were used as controls. Viral loads in all chronically infected mandrills ranged from 105 to 9 × 105 copies/ml and antibody titers ranged from 200 to 14,400 and 200 to 12,800 for anti-V3 and anti-gp36, respectively. There were no differences between groups of wild and captive mandrills. Both parameters were stable during the follow-up, and no clinical signs of immune suppression were observed. Chronic SIVmnd-1-infected mandrills presented slight increases in CD20+ and CD28+ /CD8+ cell counts, and a slight decrease in CD4+ /CD3+ cell counts. A slight CD4+ /CD3+ cell depletion was also observed in old uninfected controls. Similar to other nonpathogenic models of lentiviral infection, these results show a persistent high level of SIVmnd-1 replication during chronic infection of mandrills, with minimal effects on T cell subpopulations.en_UK
dc.language.isoen-
dc.publisherElsevier-
dc.relationPandrea I, Onanga R, Kornfeld C, Rouquet P, Bourry O, Clifford SL, Telfer PT, Abernethy K, White L, Ngari P, Muller-Trutwin M, Roques P, Marx PA, Simon F & Apetrei C (2003) High levels of SIVmnd-1 replication in chronically infected Mandrillus sphinx, Virology, 317 (1), pp. 119-127.-
dc.rightsThe publisher does not allow this work to be made publicly available in this Repository. Please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study.-
dc.subjectSIVmnd-1en_UK
dc.subjectpathogenesisen_UK
dc.subjectmandrillsen_UK
dc.subjectviral loaden_UK
dc.subjectlymphocyte subsetsen_UK
dc.titleHigh levels of SIVmnd-1 replication in chronically infected Mandrillus sphinxen_UK
dc.typeJournal Articleen_UK
dc.rights.embargodate2999-12-31T00:00:00Z-
dc.rights.embargoreasonThe publisher does not allow this work to be made publicly available in this Repository therefore there is an embargo on the full text of the work.-
dc.identifier.doihttp://dx.doi.org/10.1016/j.virol.2003.08.015-
dc.citation.jtitleVirology-
dc.citation.issn0042-6822-
dc.citation.volume317-
dc.citation.issue1-
dc.citation.spage119-
dc.citation.epage127-
dc.citation.publicationstatusPublished-
dc.citation.peerreviewedRefereed-
dc.type.statusPublisher version (final published refereed version)-
dc.author.emailk.a.abernethy@stir.ac.uk-
dc.contributor.affiliationCentre International de Recherches Médicales de Franceville-
dc.contributor.affiliationCentre International de Recherches Médicales de Franceville-
dc.contributor.affiliationInstitut Pasteur-
dc.contributor.affiliationCentre International de Recherches Médicales de Franceville-
dc.contributor.affiliationCentre International de Recherches Médicales de Franceville-
dc.contributor.affiliationCentre International de Recherches Médicales de Franceville-
dc.contributor.affiliationCentre International de Recherches Médicales de Franceville-
dc.contributor.affiliationBiological and Environmental Sciences-
dc.contributor.affiliationBiological and Environmental Sciences-
dc.contributor.affiliationCentre International de Recherches Médicales de Franceville-
dc.contributor.affiliationInstitut Pasteur-
dc.contributor.affiliationCentre International de Recherches Médicales de Franceville-
dc.contributor.affiliationTulane University-
dc.contributor.affiliationInstitut Pasteur de Dakar-
dc.contributor.affiliationCentre International de Recherches Médicales de Franceville-
dc.rights.embargoterms2999-12-31-
dc.rights.embargoliftdate2999-12-31-
dc.identifier.isi000187430800011-
Appears in Collections:Biological and Environmental Sciences Journal Articles

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