Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/20875
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dc.contributor.authorLuckenbach, Tillen_UK
dc.contributor.authorFischer, Stephanen_UK
dc.contributor.authorSturm, Arminen_UK
dc.date.accessioned2015-05-16T00:59:43Z-
dc.date.available2015-05-16T00:59:43Zen_UK
dc.date.issued2014-09en_UK
dc.identifier.urihttp://hdl.handle.net/1893/20875-
dc.description.abstractMost members of the large ATP-binding cassette (ABC) gene family are transporters involved in substrate translocation across biological membranes. In eukaryotes, ABC proteins functioning as drug transporters are located in the plasma membrane and mediate the cellular efflux of a wide range of organic chemicals, with some transporters also transporting certain metals. As the enhanced expression of ABC drug transporters can confer multidrug resistance (MDR) to cancers and multixenobiotic resistance (MXR) to organisms from polluted habitats, these ABC family members are also referred to as MDR or MXR proteins. In mammals, ABC drug transporters show predominant expression in tissues involved in excretion or constituting internal or external body boundaries, where they facilitate the excretion of chemicals and their metabolites, and limit chemical uptake and penetration into "sanctuary" sites of the body. Available knowledge about ABC proteins is still limited in teleost fish, a large vertebrate group of high ecological and economic importance. Using transport activity measurements and immunochemical approaches, early studies demonstrated similarities in the tissue distribution of ABC drug transporters between teleosts and mammals, suggesting conserved roles of the transporters in the biochemical defence against toxicants. Recently, the availability of teleost genome assemblies has stimulated studies of the ABC family in this taxon. This review summarises the current knowledge regarding the genetics, functional properties, physiological function, and ecotoxicological relevance of teleostean ABC transporters. The available literature is reviewed with emphasis on recent studies addressing the tissue distribution, substrate spectrum, regulation, physiological function and phylogenetic origin of teleostean ABC transporters.en_UK
dc.language.isoenen_UK
dc.publisherElsevieren_UK
dc.relationLuckenbach T, Fischer S & Sturm A (2014) Current advances on ABC drug transporters in fish. Comparative Biochemistry and Physiology - Part C: Toxicology and Pharmacology, 165, pp. 28-52. https://doi.org/10.1016/j.cbpc.2014.05.002.en_UK
dc.rights© 2014 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/).en_UK
dc.subjectABC gene familyen_UK
dc.subjectTeleosten_UK
dc.subjectFishen_UK
dc.subjectXenobioticen_UK
dc.subjectPollutanten_UK
dc.subjectBiochemical defenceen_UK
dc.subjectTransporten_UK
dc.titleCurrent advances on ABC drug transporters in fishen_UK
dc.typeJournal Articleen_UK
dc.identifier.doi10.1016/j.cbpc.2014.05.002en_UK
dc.citation.jtitleComparative Biochemistry and Physiology - Part C: Toxicology and Pharmacologyen_UK
dc.citation.issn1532-0456en_UK
dc.citation.volume165en_UK
dc.citation.spage28en_UK
dc.citation.epage52en_UK
dc.citation.publicationstatusPublisheden_UK
dc.citation.peerreviewedRefereeden_UK
dc.type.statusVoR - Version of Recorden_UK
dc.contributor.affiliationHelmholtz Centre for Environmental Research-UFZ, Germanyen_UK
dc.contributor.affiliationETH Zurichen_UK
dc.contributor.affiliationInstitute of Aquacultureen_UK
dc.identifier.isi000340222600004en_UK
dc.identifier.scopusid2-s2.0-84902168003en_UK
dc.identifier.wtid622726en_UK
dc.contributor.orcid0000-0003-2632-1999en_UK
dc.date.accepted2014-05-14en_UK
dc.date.firstcompliantdepositdate2014-08-12en_UK
dc.description.refREF Compliant by Deposit in Stirling's Repositoryen_UK
Appears in Collections:Aquaculture Journal Articles

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