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dc.contributor.authorKuhn, Jens Hen_UK
dc.contributor.authorBao, Yimingen_UK
dc.contributor.authorBavari, Sinaen_UK
dc.contributor.authorBecker, Stephanen_UK
dc.contributor.authorBradfute, Stevenen_UK
dc.contributor.authorBrauburger, Kristinaen_UK
dc.contributor.authorBrister, J Rodneyen_UK
dc.contributor.authorBukreyev, Alexander Aen_UK
dc.contributor.authorCai, Yingyunen_UK
dc.contributor.authorChandran, Kartiken_UK
dc.contributor.authorDavey, Robert Aen_UK
dc.contributor.authorDolnik, Olgaen_UK
dc.contributor.authorDye, John Men_UK
dc.contributor.authorEnterlein, Svenen_UK
dc.contributor.authorWeidmann, Manfreden_UK
dc.description.abstractSpecific alterations (mutations, deletions, insertions) of virus genomes are crucial for the functional characterization of their regulatory elements and their expression products, as well as a prerequisite for the creation of attenuated viruses that could serve as vaccine candidates. Virus genome tailoring can be performed either by using traditionally cloned genomes as starting materials, followed by site-directed mutagenesis, or by de novo synthesis of modified virus genomes or parts thereof. A systematic nomenclature for such recombinant viruses is necessary to set them apart from wild-type and laboratory-adapted viruses, and to improve communication and collaborations among researchers who may want to use recombinant viruses or create novel viruses based on them. A large group of filovirus experts has recently proposed nomenclatures for natural and laboratory animal-adapted filoviruses that aim to simplify the retrieval of sequence data from electronic databases. Here, this work is extended to include nomenclature for filoviruses obtained in the laboratory via reverse genetics systems. The previously developed template for natural filovirus genetic variant naming, (/)///-, is retained, but we propose to adapt the type of information added to each field for cDNA clone-derived filoviruses. For instance, the full-length designation of an Ebola virus Kikwit variant rescued from a plasmid developed at the US Centers for Disease Control and Prevention could be akin to "Ebola virus H.sapiens-rec/COD/1995/Kikwit-abc1" (with the suffix "rec" identifying the recombinant nature of the virus and "abc1" being a placeholder for any meaningful isolate designator). Such a full-length designation should be used in databases and the methods section of publications. Shortened designations (such as "EBOV") and abbreviations (such as "EBOV/Kik-abc1") could be used in the remainder of the text, depending on how critical it is to convey information contained in the full-length name. "EBOV" would suffice if only one EBOV strain/variant/isolate is addressed.en_UK
dc.relationKuhn JH, Bao Y, Bavari S, Becker S, Bradfute S, Brauburger K, Brister JR, Bukreyev AA, Cai Y, Chandran K, Davey RA, Dolnik O, Dye JM, Enterlein S & Weidmann M (2014) Virus nomenclature below the species level: a standardized nomenclature for filovirus strains and variants rescued from cDNA. Archives of Virology, 159 (5), pp. 1229-1237.
dc.rightsThe publisher does not allow this work to be made publicly available in this Repository. Please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study.en_UK
dc.titleVirus nomenclature below the species level: a standardized nomenclature for filovirus strains and variants rescued from cDNAen_UK
dc.typeJournal Articleen_UK
dc.rights.embargoreason[Archives of Virology 2014.pdf] The publisher does not allow this work to be made publicly available in this Repository therefore there is an embargo on the full text of the work.en_UK
dc.citation.jtitleArchives of Virologyen_UK
dc.type.statusVoR - Version of Recorden_UK
dc.description.notesAdditional authors: Jean-Paul Gonzalez, Pierre Formenty, Alexander N. Freiberg, Lisa E. Hensley, Thomas Hoenen, Anna N. Honko, Georgy M. Ignatyev, Peter B. Jahrling, Karl M. Johnson, Hans-Dieter Klenk, Gary Kobinger, Matthew G. Lackemeyer, Eric M. Leroy, Mark S. Lever, Elke Mühlberger, Sergey V. Netesov, Gene G. Olinger, Gustavo Palacios, Jean L. Patterson, Janusz T. Paweska, Louise Pitt, Sheli R. Radoshitzky, Elena I. Ryabchikova, Erica Ollmann Saphire, Aleksandr M. Shestopalov, Sophie J. Smither, Nancy J. Sullivan, Robert Swanepoel, Ayato Takada, Jonathan S. Towner, Guido van der Groen, Viktor E. Volchkov, Valentina A. Volchkova, Victoria Wahl-Jensen, Travis K. Warren, Kelly L. Warfield, Stuart T. Nicholen_UK
dc.contributor.affiliationNational Institutes of Health (US)en_UK
dc.contributor.affiliationNational Institutes of Health (US)en_UK
dc.contributor.affiliationUnited States (US) Army - Medical Research Institute of Infectious Diseasesen_UK
dc.contributor.affiliationPhilipps University of Marburgen_UK
dc.contributor.affiliationUniversity of New Mexico, USAen_UK
dc.contributor.affiliationBoston Universityen_UK
dc.contributor.affiliationNational Institutes of Health (US)en_UK
dc.contributor.affiliationUniversity of Texas Medical Branchen_UK
dc.contributor.affiliationNational Institutes of Health (US)en_UK
dc.contributor.affiliationAlbert Einstein College of Medicine of Yeshiva Universityen_UK
dc.contributor.affiliationTexas Biomedical Research Instituteen_UK
dc.contributor.affiliationPhilipps University of Marburgen_UK
dc.contributor.affiliationUnited States (US) Army - Medical Research Institute of Infectious Diseasesen_UK
dc.contributor.affiliationIntegrated BioTherapeutics Incen_UK
dc.contributor.affiliationInstitute of Aquacultureen_UK
rioxxterms.apcnot requireden_UK
rioxxterms.typeJournal Article/Reviewen_UK
local.rioxx.authorKuhn, Jens H|en_UK
local.rioxx.authorBao, Yiming|en_UK
local.rioxx.authorBavari, Sina|en_UK
local.rioxx.authorBecker, Stephan|en_UK
local.rioxx.authorBradfute, Steven|en_UK
local.rioxx.authorBrauburger, Kristina|en_UK
local.rioxx.authorBrister, J Rodney|en_UK
local.rioxx.authorBukreyev, Alexander A|en_UK
local.rioxx.authorCai, Yingyun|en_UK
local.rioxx.authorChandran, Kartik|en_UK
local.rioxx.authorDavey, Robert A|en_UK
local.rioxx.authorDolnik, Olga|en_UK
local.rioxx.authorDye, John M|en_UK
local.rioxx.authorEnterlein, Sven|en_UK
local.rioxx.authorWeidmann, Manfred|0000-0002-7063-7491en_UK
local.rioxx.projectInternal Project|University of Stirling|
local.rioxx.filenameArchives of Virology 2014.pdfen_UK
Appears in Collections:Aquaculture Journal Articles

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