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dc.contributor.authorDesbois, Andrew P-
dc.description.abstractDrug discovery from marine organisms has been underway for > 60 years and there have been notable successes in discovering, developing and introducing clinical agents derived from marine sources. Such examples include: the analgesic ziconotide and the anti cancer compound trabectedin. However, in light of the pressing need for new drugs, particularly those with anti-infective and anticancer properties, there is strong justification for increased exploration of marine organisms as sources of novel compounds. This article considers approaches that might enhance our chances of delivering new medicines from marine-based drug discovery efforts. Consideration is given to the organisms and habitats deserving of more attention and how we might make best use of these marine genetic resources. In particular, the opportunities offered by synthetic biology are highlighted because these methods allow drug discoverers to explore pathways in 'non-culturable' species and turn on natural product biosynthesis genes that are difficult to activate under laboratory conditions (so-called 'silent' gene clusters).en_UK
dc.publisherInforma Healthcare-
dc.relationDesbois AP (2014) How might we increase success in marine-based drug discovery? (Editorial), Expert Opinion on Drug Discovery, 9 (9), pp. 985-990.-
dc.rightsThe publisher does not allow this work to be made publicly available in this Repository. Please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study.-
dc.subjectcombinatorial biosynthesisen_UK
dc.subjectinfectious diseaseen_UK
dc.subjectnatural productsen_UK
dc.subjectsynthetic biologyen_UK
dc.titleHow might we increase success in marine-based drug discovery? (Editorial)en_UK
dc.typeJournal Articleen_UK
dc.rights.embargoreasonThe publisher does not allow this work to be made publicly available in this Repository therefore there is an embargo on the full text of the work.-
dc.citation.jtitleExpert Opinion on Drug Discovery-
dc.type.statusPublisher version (final published refereed version)-
Appears in Collections:Biological and Environmental Sciences Journal Articles

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