Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/20221
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dc.contributor.authorMcGlory, Chrisen_UK
dc.contributor.authorGalloway, S Den_UK
dc.contributor.authorHamilton, David Leeen_UK
dc.contributor.authorMcClintock, Craigen_UK
dc.contributor.authorBreen, Leighen_UK
dc.contributor.authorDick, James Ren_UK
dc.contributor.authorBell, J Gordonen_UK
dc.contributor.authorTipton, Kevinen_UK
dc.date.accessioned2016-08-17T01:05:11Z-
dc.date.available2016-08-17T01:05:11Z-
dc.date.issued2014-06en_UK
dc.identifier.urihttp://hdl.handle.net/1893/20221-
dc.description.abstractThe aim of this study was to examine changes in the lipid profile of red blood cells and muscle tissue along with the expression of anabolic signalling proteins in human skeletal muscle. Following a 2-week control period, 10 healthy male participants consumed 5 g d-1 of fish oil (FO) for 4 weeks. Muscle biopsies and venous blood samples were collected in the fasted state 2 weeks prior (W-2) and immediately before (W0) the initiation of FO supplementation for internal control. Muscle biopsies and venous blood samples were again obtained at week 1 (W1), 2 (W2) and 4 (W4) during FO supplementation for assessment of changes in lipid composition and expression of anabolic signalling proteins. There was no change in the composition of any lipid class between W-2 and W0 confirming control. Following FO supplementation n-3 polyunsaturated fatty acid (n-3 PUFA) muscle lipid composition was increased from W0 to W2 and continued to rise at W4. n-3 PUFA blood lipid composition was increased from W0 to W1 and remained elevated for the remaining time points. Total protein content of focal adhesion kinase (FAK) increased from W0 to W4 whereas total mechanistic target of rapamycin (mTOR) was increased from W0 at W1 with no further significant increases at W2 and W4. These data show that FO supplementation results in discordant changes in the n-3 PUFA composition of skeletal muscle compared to blood that is associated with increases in total FAK content.en_UK
dc.language.isoenen_UK
dc.publisherElsevieren_UK
dc.relationMcGlory C, Galloway SD, Hamilton DL, McClintock C, Breen L, Dick JR, Bell JG & Tipton K (2014) Temporal changes in human skeletal muscle and blood lipid composition with fish oil supplementation. Prostaglandins, Leukotrienes and Essential Fatty Acids, 90 (6), pp. 199-206. https://doi.org/10.1016/j.plefa.2014.03.001en_UK
dc.rightsThe publisher does not allow this work to be made publicly available in this Repository. Please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study.en_UK
dc.rights.urihttp://www.rioxx.net/licenses/under-embargo-all-rights-reserveden_UK
dc.subjectn-3 PUFAen_UK
dc.subjectMuscleen_UK
dc.subjectFAKen_UK
dc.titleTemporal changes in human skeletal muscle and blood lipid composition with fish oil supplementationen_UK
dc.typeJournal Articleen_UK
dc.rights.embargodate2999-12-31en_UK
dc.rights.embargoreason[PLEFA 2014.pdf] The publisher does not allow this work to be made publicly available in this Repository therefore there is an embargo on the full text of the work.en_UK
dc.identifier.doi10.1016/j.plefa.2014.03.001en_UK
dc.citation.jtitleProstaglandins, Leukotrienes and Essential Fatty Acidsen_UK
dc.citation.issn0952-3278en_UK
dc.citation.volume90en_UK
dc.citation.issue6en_UK
dc.citation.spage199en_UK
dc.citation.epage206en_UK
dc.citation.publicationstatusPublisheden_UK
dc.citation.peerreviewedRefereeden_UK
dc.type.statusVoR - Version of Recorden_UK
dc.contributor.funderSporting Chance Initiativeen_UK
dc.author.emails.d.r.galloway@stir.ac.uken_UK
dc.contributor.affiliationUniversity of Stirlingen_UK
dc.contributor.affiliationSporten_UK
dc.contributor.affiliationSporten_UK
dc.contributor.affiliationUniversity of Stirlingen_UK
dc.contributor.affiliationUniversity of Birminghamen_UK
dc.contributor.affiliationInstitute of Aquacultureen_UK
dc.contributor.affiliationInstitute of Aquacultureen_UK
dc.contributor.affiliationSporten_UK
dc.identifier.isiWOS:000336698700001en_UK
dc.identifier.scopusid2-s2.0-84897366039en_UK
dc.identifier.wtid629723en_UK
dc.contributor.orcid0000-0002-1622-3044en_UK
dc.contributor.orcid0000-0002-5620-4788en_UK
dc.contributor.orcid0000-0002-6545-8122en_UK
dc.date.accepted2014-03-19en_UK
dcterms.dateAccepted2014-03-19en_UK
dc.date.filedepositdate2014-05-16en_UK
dc.relation.funderprojectSporting Chance Initiative - STAR Granten_UK
dc.relation.funderref0en_UK
rioxxterms.apcnot requireden_UK
rioxxterms.typeJournal Article/Reviewen_UK
rioxxterms.versionVoRen_UK
local.rioxx.authorMcGlory, Chris|en_UK
local.rioxx.authorGalloway, S D|0000-0002-1622-3044en_UK
local.rioxx.authorHamilton, David Lee|0000-0002-5620-4788en_UK
local.rioxx.authorMcClintock, Craig|en_UK
local.rioxx.authorBreen, Leigh|en_UK
local.rioxx.authorDick, James R|en_UK
local.rioxx.authorBell, J Gordon|en_UK
local.rioxx.authorTipton, Kevin|0000-0002-6545-8122en_UK
local.rioxx.project0|Sporting Chance Initiative|en_UK
local.rioxx.freetoreaddate2999-12-31en_UK
local.rioxx.licencehttp://www.rioxx.net/licenses/under-embargo-all-rights-reserved||en_UK
local.rioxx.filenamePLEFA 2014.pdfen_UK
local.rioxx.filecount1en_UK
local.rioxx.source0952-3278en_UK
Appears in Collections:Aquaculture Journal Articles

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