Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/20197
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dc.contributor.authorWilliams, Tim D-
dc.contributor.authorDavies, Ian M-
dc.contributor.authorWu, Huifeng-
dc.contributor.authorDiab, Amer-
dc.contributor.authorWebster, Lynda-
dc.contributor.authorViant, Mark R-
dc.contributor.authorChipman, James Kevin-
dc.contributor.authorLeaver, Michael-
dc.contributor.authorGeorge, Stephen-
dc.contributor.authorMoffat, Colin F-
dc.contributor.authorRobinson, Craig D-
dc.date.accessioned2015-10-20T01:00:13Z-
dc.date.available2015-10-20T01:00:13Z-
dc.date.issued2014-08-
dc.identifier.urihttp://hdl.handle.net/1893/20197-
dc.description.abstractMolecular responses to acute toxicant exposure can be effective biomarkers, however responses to chronic exposure are less well characterised. The aim of this study was to determine chronic molecular responses to environmental mixtures in a controlled laboratory setting, free from the additional variability encountered with environmental sampling of wild organisms. Flounder fish were exposed in mesocosms for seven months to a contaminated estuarine sediment made by mixing material from the Forth (high organics) and Tyne (high metals and tributyltin) estuaries (FT) or a reference sediment from the Ythan estuary (Y). Chemical analyses demonstrated that FT sediment contained significantly higher concentrations of key environmental pollutants (including polycyclic aromatic hydrocarbons (PAHs), chlorinated biphenyls and heavy metals) than Y sediment, but that chronically exposed flounder showed a lack of differential accumulation of contaminants, including heavy metals. Biliary 1-hydroxypyrene concentration and erythrocyte DNA damage increased in FT-exposed fish. Transcriptomic and 1H NMR metabolomic analyses of liver tissues detected small but statistically significant alterations between fish exposed to different sediments. These highlighted perturbance of immune response and apoptotic pathways, but there was a lack of response from traditional biomarker genes. Gene-chemical association annotation enrichment analyses suggested that polycyclic aromatic hydrocarbons were a major class of toxicants affecting the molecular responses of the exposed fish. This demonstrated that molecular responses of sentinel organisms can be detected after chronic mixed toxicant exposure and that these can be informative of key components of the mixture.en_UK
dc.language.isoen-
dc.publisherElsevier-
dc.relationWilliams TD, Davies IM, Wu H, Diab A, Webster L, Viant MR, Chipman JK, Leaver M, George S, Moffat CF & Robinson CD (2014) Molecular responses of European flounder (Platichthys flesus) chronically exposed to contaminated estuarine sediments, Chemosphere, 108, pp. 152-158.-
dc.rightshttp://dx.doi.org/10.1016/j.chemosphere.2014.01.028 0045-6535/ (c) 2014 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/3.0/).-
dc.subjectSedimentsen_UK
dc.subjectFlounderen_UK
dc.subjectToxicogenomicsen_UK
dc.subjectMicroarrayen_UK
dc.subjectMetabolomicsen_UK
dc.subjectGenotoxicityen_UK
dc.titleMolecular responses of European flounder (Platichthys flesus) chronically exposed to contaminated estuarine sedimentsen_UK
dc.typeJournal Articleen_UK
dc.identifier.doihttp://dx.doi.org/10.1016/j.chemosphere.2014.01.028-
dc.identifier.pmid24534155-
dc.citation.jtitleChemosphere-
dc.citation.issn0045-6535-
dc.citation.volume108-
dc.citation.spage152-
dc.citation.epage158-
dc.citation.publicationstatusPublished-
dc.citation.peerreviewedRefereed-
dc.type.statusPublisher version (final published refereed version)-
dc.author.emailm.j.leaver@stir.ac.uk-
dc.citation.date15/02/2014-
dc.contributor.affiliationUniversity of Birmingham-
dc.contributor.affiliationScottish Government - Enterprise, Environment & Digital - Marine Scotland-
dc.contributor.affiliationUniversity of Birmingham-
dc.contributor.affiliationAquaculture-
dc.contributor.affiliationScottish Government - Enterprise, Environment & Digital - Marine Scotland-
dc.contributor.affiliationUniversity of Birmingham-
dc.contributor.affiliationUniversity of Birmingham-
dc.contributor.affiliationAquaculture-
dc.contributor.affiliationAquaculture-
dc.contributor.affiliationScottish Government - Enterprise, Environment & Digital - Marine Scotland-
dc.contributor.affiliationScottish Government - Enterprise, Environment & Digital - Marine Scotland-
dc.identifier.isi000337881600020-
Appears in Collections:Aquaculture Journal Articles

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