Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/20076
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dc.contributor.authorBekaert, Michaëlen_UK
dc.contributor.authorConant, Gavin Cen_UK
dc.date.accessioned2018-04-20T01:10:40Z-
dc.date.available2018-04-20T01:10:40Z-
dc.date.issued2014-01en_UK
dc.identifier.othere87115en_UK
dc.identifier.urihttp://hdl.handle.net/1893/20076-
dc.description.abstractMetabolic networks attempt to describe the complete suite of biochemical reactions available to an organism. One notable feature of these networks in mammals is the large number of distinct proteins that catalyze the same reaction. While the existence of these isoenzymes has long been known, their evolutionary significance is still unclear. Using a phylogenetically-aware comparative genomics approach, we infer enzyme orthology networks for sixteen mammals as well as for their common ancestors. We find that the pattern of isoenzymes copy-number alterations (CNAs) in these networks is suggestive of natural selection acting on the retention of certain gene duplications. When further analyzing these data with a machine-learning approach, we found that that the pattern of CNAs is also predictive of several important phenotypic traits, including milk composition and geographic range. Integrating tools from network analyses, phylogenetics and comparative genomics both allows the prediction of phenotypes from genetic data and represents a means of unifying distinct biological disciplines.en_UK
dc.language.isoenen_UK
dc.publisherPublic Library of Scienceen_UK
dc.relationBekaert M & Conant GC (2014) Gene duplication and phenotypic changes in the evolution of Mammalian metabolic networks. PLoS ONE, 9 (1), Art. No.: e87115. https://doi.org/10.1371/journal.pone.0087115en_UK
dc.rights© 2014 Bekaert, Conant. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.en_UK
dc.titleGene duplication and phenotypic changes in the evolution of Mammalian metabolic networksen_UK
dc.typeJournal Articleen_UK
dc.identifier.doi10.1371/journal.pone.0087115en_UK
dc.identifier.pmid24489850en_UK
dc.citation.jtitlePLoS ONEen_UK
dc.citation.issn1932-6203en_UK
dc.citation.volume9en_UK
dc.citation.issue1en_UK
dc.citation.publicationstatusPublisheden_UK
dc.citation.peerreviewedRefereeden_UK
dc.type.statusVoR - Version of Recorden_UK
dc.author.emailmichael.bekaert@stir.ac.uken_UK
dc.citation.date28/01/2014en_UK
dc.contributor.affiliationInstitute of Aquacultureen_UK
dc.contributor.affiliationUniversity of Missouri - Columbiaen_UK
dc.identifier.isiWOS:000330510000109en_UK
dc.identifier.scopusid2-s2.0-84900303150en_UK
dc.identifier.wtid886381en_UK
dc.contributor.orcid0000-0002-1206-7654en_UK
dc.date.accepted2013-12-23en_UK
dc.description.refREF Compliant by Deposit in Stirling's Repositoryen_UK
dc.date.filedepositdate2014-05-06en_UK
Appears in Collections:Aquaculture Journal Articles

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