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Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/19814
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dc.contributor.authorLucas-Sanchez, Alejandroen_UK
dc.contributor.authorAlmaida, Pedroen_UK
dc.contributor.authorTocher, Douglas Ren_UK
dc.contributor.authorMendiola, Pilaren_UK
dc.contributor.authorde Costa, Jorgeen_UK
dc.date.accessioned2018-01-27T03:54:40Z-
dc.date.available2018-01-27T03:54:40Z-
dc.date.issued2014-02en_UK
dc.identifier.urihttp://hdl.handle.net/1893/19814-
dc.description.abstractMitochondrial membrane composition may be a critical factor in the mechanisms of the aging process by influencing the propagation of reactions involved in mitochondrial function during periods of high stress. Changes affecting either lipid class or fatty acid compositions could affect phospholipid properties and alter mitochondrial function and cell viability. In the present study, mitochondrial membrane phospholipid compositions were analyzed throughout the life cycle of Nothobranchius rachovii. Mitochondrial phospholipids showed several changes with age. Proportions of cardiolipin decreased and those of sphingomyelin increased between 11- and 14-month-old fish. Fatty acid compositions of indi- vidual phospholipids in mitochondria were also significantly affected with age. These data suggest increasing damage to mitochondrial lipids during the life cycle of N. rachovii that could be one of the main factors related with and contributing to degraded mitochondrial function associated with the aging process.en_UK
dc.language.isoenen_UK
dc.publisherOxford University Pressen_UK
dc.relationLucas-Sanchez A, Almaida P, Tocher DR, Mendiola P & de Costa J (2014) Age-related changes in mitochondrial membrane composition of Nothobranchius rachovii. Journals of Gerontology, Series A, 69 A (2), pp. 142-151. https://doi.org/10.1093/gerona/glt066en_UK
dc.rightsThe publisher does not allow this work to be made publicly available in this Repository. Please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study.en_UK
dc.rights.urihttp://www.rioxx.net/licenses/under-embargo-all-rights-reserveden_UK
dc.subjectAgingen_UK
dc.subjectMitochondriaen_UK
dc.subjectPhospholipiden_UK
dc.subjectFatty aciden_UK
dc.subjectFishen_UK
dc.titleAge-related changes in mitochondrial membrane composition of Nothobranchius rachoviien_UK
dc.typeJournal Articleen_UK
dc.rights.embargodate2999-12-29en_UK
dc.rights.embargoreason[Age-related changes in mitochondrial membrane composition.pdf] The publisher does not allow this work to be made publicly available in this Repository therefore there is an embargo on the full text of the work.en_UK
dc.identifier.doi10.1093/gerona/glt066en_UK
dc.citation.jtitleJournals of Gerontology, Series Aen_UK
dc.citation.issn1758-535Xen_UK
dc.citation.issn1079-5006en_UK
dc.citation.volume69 Aen_UK
dc.citation.issue2en_UK
dc.citation.spage142en_UK
dc.citation.epage151en_UK
dc.citation.publicationstatusPublisheden_UK
dc.citation.peerreviewedRefereeden_UK
dc.type.statusVoR - Version of Recorden_UK
dc.contributor.funderEuropean Commissionen_UK
dc.author.emaildrt1@stir.ac.uken_UK
dc.contributor.affiliationUniversity of Murciaen_UK
dc.contributor.affiliationInstitute of Aquacultureen_UK
dc.contributor.affiliationInstitute of Aquacultureen_UK
dc.contributor.affiliationUniversity of Murciaen_UK
dc.contributor.affiliationUniversity of Murciaen_UK
dc.identifier.isiWOS:000333384700003en_UK
dc.identifier.scopusid2-s2.0-84896778365en_UK
dc.identifier.wtid635584en_UK
dc.contributor.orcid0000-0002-8603-9410en_UK
dc.date.accepted2013-04-09en_UK
dcterms.dateAccepted2013-04-09en_UK
dc.date.filedepositdate2014-04-14en_UK
dc.relation.funderprojectOxidation, Lipids, DNA and Mitochondriaen_UK
dc.relation.funderrefPIEF-GA-2011-297964en_UK
rioxxterms.apcnot requireden_UK
rioxxterms.typeJournal Article/Reviewen_UK
rioxxterms.versionVoRen_UK
local.rioxx.authorLucas-Sanchez, Alejandro|en_UK
local.rioxx.authorAlmaida, Pedro|en_UK
local.rioxx.authorTocher, Douglas R|0000-0002-8603-9410en_UK
local.rioxx.authorMendiola, Pilar|en_UK
local.rioxx.authorde Costa, Jorge|en_UK
local.rioxx.projectPIEF-GA-2011-297964|European Commission (Horizon 2020)|en_UK
local.rioxx.freetoreaddate2999-12-29en_UK
local.rioxx.licencehttp://www.rioxx.net/licenses/under-embargo-all-rights-reserved||en_UK
local.rioxx.filenameAge-related changes in mitochondrial membrane composition.pdfen_UK
local.rioxx.filecount1en_UK
local.rioxx.source1079-5006en_UK
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