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dc.contributor.authorWevers, Diana-
dc.contributor.authorMetzger, Sonja-
dc.contributor.authorBabweteera, Fred-
dc.contributor.authorBieberbach, Marc-
dc.contributor.authorBoesch, Christophe-
dc.contributor.authorCameron, Kenneth-
dc.contributor.authorCouacy-Hymann, Emmanuel-
dc.contributor.authorCranfield, Mike-
dc.contributor.authorGray, Maryke-
dc.contributor.authorHarris, Laurie A-
dc.contributor.authorHead, Josephine-
dc.contributor.authorJeffery, Kathryn Jane-
dc.contributor.authorKnauf, Sascha-
dc.contributor.authorLankester, Felix-
dc.contributor.authorLeendertz, Siv Aina J-
dc.description.abstractAdenoviruses (AdVs) broadly infect vertebrate hosts, including a variety of nonhuman primates (NHPs). In the present study, we identified AdVs in NHPs living in their natural habitats, and through the combination of phylogenetic analyses and information on the habitats and epidemiological settings, we detected possible horizontal transmission events between NHPs and humans. Wild NHPs were analyzed with a pan-primate AdV-specific PCR using a degenerate nested primer set that targets the highly conserved adenovirus DNA polymerase gene. A plethora of novel AdV sequences were identified, representing at least 45 distinct AdVs. From the AdV-positive individuals, 29 nearly complete hexon genes were amplified and, based on phylogenetic analysis, tentatively allocated to all known human AdV species (Human adenovirus A to Human adenovirus G [HAdV-A to -G]) as well as to the only simian AdV species (Simian adenovirus A [SAdV-A]). Interestingly, five of the AdVs detected in great apes grouped into the HAdV-A, HAdV-D, HAdV-F, or SAdV-A clade. Furthermore, we report the first detection of AdVs in New World monkeys, clustering at the base of the primate AdV evolutionary tree. Most notably, six chimpanzee AdVs of species HAdV-A to HAdV-F revealed a remarkably close relationship to human AdVs, possibly indicating recent interspecies transmission events.en_UK
dc.publisherAmerican Society for Microbiology-
dc.relationWevers D, Metzger S, Babweteera F, Bieberbach M, Boesch C, Cameron K, Couacy-Hymann E, Cranfield M, Gray M, Harris LA, Head J, Jeffery KJ, Knauf S, Lankester F & Leendertz SAJ (2011) Novel adenoviruses in wild primates: a high level of genetic diversity and evidence of zoonotic transmissions, Journal of Virology, 85 (20), pp. 10774-10784.-
dc.rightsThe publisher does not allow this work to be made publicly available in this Repository. Please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study.-
dc.titleNovel adenoviruses in wild primates: a high level of genetic diversity and evidence of zoonotic transmissionsen_UK
dc.typeJournal Articleen_UK
dc.rights.embargoreasonThe publisher does not allow this work to be made publicly available in this Repository therefore there is an embargo on the full text of the work.-
dc.citation.jtitleJournal of Virology-
dc.type.statusPublisher version (final published refereed version)-
dc.description.notesAdditional co-authors: Elizabeth Lonsdorf, Lawrence Mugisha, Andreas Nitsche, Patricia Reed, Martha Robbins, Dominic A. Travis, Zinta Zommers, Fabian H. Leendertz and Bernhard Ehlersen_UK
dc.contributor.affiliationRobert Koch Institute-
dc.contributor.affiliationRobert Koch Institute-
dc.contributor.affiliationBudongo Conservation Field Station-
dc.contributor.affiliationRobert Koch Institute-
dc.contributor.affiliationUniversity Leipzig-
dc.contributor.affiliationWildlife Conservation Society, Africa-
dc.contributor.affiliationLaboratoire National d'Appui au Développement Agricole - LANADA (Laborotoire Central de la Pathologie Animale)-
dc.contributor.affiliationMountain Gorilla Veterinary Project-
dc.contributor.affiliationInternational Gorilla Conservation Programme-
dc.contributor.affiliationUniversity of California, Davis-
dc.contributor.affiliationMax Planck Institute for Evolutionary Anthropology-
dc.contributor.affiliationBiological and Environmental Sciences-
dc.contributor.affiliationGerman Primate Center-
dc.contributor.affiliationLincoln Park Zoo-
dc.contributor.affiliationRobert Koch Institute-
Appears in Collections:Biological and Environmental Sciences Journal Articles

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