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Appears in Collections:Psychology Journal Articles
Peer Review Status: Refereed
Title: The association of visceral adiposity with cardiovascular events in patients with peripheral artery disease
Author(s): Cronin, Oliver
Bradshaw, Barbara
Iyer, Vikram
Cunningham, Margaret
Buttner, Petra
Walker, Philip J
Golledge, Jonathan
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Issue Date: Dec-2013
Date Deposited: 20-Mar-2014
Citation: Cronin O, Bradshaw B, Iyer V, Cunningham M, Buttner P, Walker PJ & Golledge J (2013) The association of visceral adiposity with cardiovascular events in patients with peripheral artery disease. PLoS ONE, 8 (12), Art. No.: e82350.
Abstract: BACKGROUND Previous studies have suggested that patients with peripheral artery disease (PAD) suffer from a high incidence of cardiovascular events (CVE). Visceral adiposity has been implicated in promoting CVEs. This study aimed to assess the association of relative visceral adipose volume with incident cardiovascular events in patients with peripheral artery disease. METHODS This was a prospective cohort study including 260 patients with PAD who presented between 2003 and 2012. Cases were patients with diagnosed PAD including symptomatic lower limb athero-thrombosis and asymptomatic abdominal aortic aneurysm. All patients underwent computed tomography angiography (CTA). Abdominal visceral to total adipose volume ratio (relative visceral adipose volume) was estimated from CTAs using a previously validated workstation protocol. Cardiovascular risk factors were recorded at entry. The association of visceral adiposity with major CVEs (death, non-fatal myocardial infarction or stroke) was examined using Kaplan Meier and Cox proportional hazard analyses. RESULTS A total of 92 major CVEs were recorded in 76 patients during a median follow-up of 2.8 (IQR 1.2 to 4.8) years, including myocardial infarction (n = 26), stroke (n = 10) and death (n = 56). At 3 years the incidence of major CVEs stratified by relative visceral adipose volume quartiles were 15% [Quartile (Q) 1], 17% (Q2), 11% (Q3) and 15% (Q4) (P = 0.517). Relative visceral adipose volume was not associated with major CVEs after adjustment for other risk factors. CONCLUSION This study suggests that visceral adiposity does not play a central role in the predisposition for major CVEs in patients with PAD.
DOI Link: 10.1371/journal.pone.0082350
Rights: © 2013 Cronin et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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