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dc.contributor.authorMowlds, Peteren_UK
dc.contributor.authorCoates, Christopheren_UK
dc.contributor.authorRenwick, Julieen_UK
dc.contributor.authorKavanagh, Kevinen_UK
dc.description.abstractGalleria mellonella larvae were inoculated with different doses of β-glucan by injection into the haemocoel. Those larvae that had received high doses of β-glucan (15, 30 or 60 μg/larva) demonstrated increased survival following infection with the yeast Candida albicans. High concentrations of glucan induced an increase in haemocyte density and a reduction in yeast proliferation within the haemocoel. Proteomic analysis of glucan-treated larvae revealed increased expression of a variety of peptides some of which may possess antimicrobial properties. Analysis of expression profiles revealed that low doses of β-glucan (3.75 μg/larva) triggered the increased expression of certain peptides (e.g. hemolin) while high dose inoculation was required before the increased expression of others (e.g. archaemetzincin) was evident. These results indicate that low doses of β-glucan induce a limited immune response while high doses induce an immune response that has the potential to curtail the threat within the haemocoel but also withstand a subsequent infection. Immune priming gives insects the ability to withstand a potentially lethal infection if exposed to a low level of the pathogen 24-48 h previously. Immune priming has resource implications and this work indicates that a graded immune response is initiated depending upon the amount of the immune priming agent encountered.en_UK
dc.relationMowlds P, Coates C, Renwick J & Kavanagh K (2010) Dose-dependent cellular and humoral responses in Galleria mellonella larvae following beta-glucan inoculation. Microbes and Infection, 12 (2), pp. 146-153.
dc.rightsThe publisher does not allow this work to be made publicly available in this Repository. Please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study.en_UK
dc.subjectAntimicrobial peptidesen_UK
dc.subjectGalleria larvaeen_UK
dc.subjectImmune responseen_UK
dc.titleDose-dependent cellular and humoral responses in Galleria mellonella larvae following beta-glucan inoculationen_UK
dc.typeJournal Articleen_UK
dc.rights.embargoreason[1_Mowlds et al 2010 Microb Infect.pdf] The publisher does not allow this work to be made publicly available in this Repository therefore there is an embargo on the full text of the work.en_UK
dc.citation.jtitleMicrobes and Infectionen_UK
dc.type.statusVoR - Version of Recorden_UK
dc.contributor.affiliationNational University of Ireland - Maynoothen_UK
dc.contributor.affiliationBiological and Environmental Sciencesen_UK
dc.contributor.affiliationNational University of Ireland - Maynoothen_UK
dc.contributor.affiliationNational University of Ireland - Maynoothen_UK
rioxxterms.typeJournal Article/Reviewen_UK
local.rioxx.authorMowlds, Peter|en_UK
local.rioxx.authorCoates, Christopher|en_UK
local.rioxx.authorRenwick, Julie|en_UK
local.rioxx.authorKavanagh, Kevin|en_UK
local.rioxx.projectInternal Project|University of Stirling|
local.rioxx.filename1_Mowlds et al 2010 Microb Infect.pdfen_UK
Appears in Collections:Biological and Environmental Sciences Journal Articles

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