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dc.contributor.authorErgunay, Korayen_UK
dc.contributor.authorSaygan, Mehmet Ben_UK
dc.contributor.authorAydogan, Sibelen_UK
dc.contributor.authorLo, Modou Moustaphaen_UK
dc.contributor.authorWeidmann, Manfreden_UK
dc.contributor.authorDilcher, Meiken_UK
dc.contributor.authorSener, Burcinen_UK
dc.contributor.authorHascelik, Gulsenen_UK
dc.contributor.authorPinar, Ahmeten_UK
dc.contributor.authorUs, Durdalen_UK
dc.description.abstractSandfly fever viruses (SFVs) cause febrile diseases as well as aseptic meningitis/encephalitis and include serotypes sandfly fever Sicilian virus (SFSV), sandfly fever Naples virus (SFNV) and Toscana virus (TOSV). Infections are endemic in the Mediterranean basin and data on SFV activity in Turkey are limited. In this study, sera from 1533 blood donors from the Ankara, Konya, Eskisehir and Zonguldak provinces of Turkey were evaluated for SFV exposure by indirect immunofluorescence test (IIFT) and confirmed by virus neutralization test (VNT). One hundred and two patients with central nervous system (CNS) infections of unknown aetiology were also tested via IIFT and real-time reverse-transcription PCR for SFV/TOSV. Rate of overall IgG reactivity in IIFT was 32.9% (505/1533) among blood donors. TOSV exposure was confirmed by VNT in all study regions. Exposure to the recently-identified serotype sandfly fever Turkish virus, as evaluated by VNT, was revealed in Konya and Ankara. SFNV exposure was identified in Konya and SFSV was observed to be present in all regions except Zonguldak. TOSV RNA was detected in 15.7% (16/102) and was accompanied by TOSV IgM in 25% (4/16) of the patients. Partial L and S sequences suggested that TOSV circulating in Turkey can be grouped into TOSV genotype A strains. Exposure to TOSV and other SFV serotypes was revealed in blood donors and CNS infections by TOSV were identified for the first time in Turkey. Infections are observed to be endemic in central Anatolia and should be considered as aetiologic agents in cases/outbreaks of fever and meningoencephalitis.en_UK
dc.publisherWiley-Blackwell for European Society of Clinical Microbiology and Infectious Diseasesen_UK
dc.relationErgunay K, Saygan MB, Aydogan S, Lo MM, Weidmann M, Dilcher M, Sener B, Hascelik G, Pinar A & Us D (2011) Sandfly fever virus activity in central/northern Anatolia, Turkey: first report of Toscana virus infections. Clinical Microbiology and Infection, 17 (4), pp. 575-581.
dc.rightsThe publisher does not allow this work to be made publicly available in this Repository. Please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study.en_UK
dc.subjectsandfly fever virusen_UK
dc.subjectToscana virusen_UK
dc.titleSandfly fever virus activity in central/northern Anatolia, Turkey: first report of Toscana virus infectionsen_UK
dc.typeJournal Articleen_UK
dc.rights.embargoreason[CMI 2011.pdf] The publisher does not allow this work to be made publicly available in this Repository therefore there is an embargo on the full text of the work.en_UK
dc.citation.jtitleClinical Microbiology and Infectionen_UK
dc.type.statusVoR - Version of Recorden_UK
dc.contributor.affiliationHacettepe Universityen_UK
dc.contributor.affiliationTurkish Red Crescent Societyen_UK
dc.contributor.affiliationHacettepe Universityen_UK
dc.contributor.affiliationGeorg-August University Gottingenen_UK
dc.contributor.affiliationInstitute of Aquacultureen_UK
dc.contributor.affiliationGeorg-August University Gottingenen_UK
dc.contributor.affiliationHacettepe Universityen_UK
dc.contributor.affiliationHacettepe Universityen_UK
dc.contributor.affiliationHacettepe Universityen_UK
dc.contributor.affiliationHacettepe Universityen_UK
rioxxterms.typeJournal Article/Reviewen_UK
local.rioxx.authorErgunay, Koray|en_UK
local.rioxx.authorSaygan, Mehmet B|en_UK
local.rioxx.authorAydogan, Sibel|en_UK
local.rioxx.authorLo, Modou Moustapha|en_UK
local.rioxx.authorWeidmann, Manfred|0000-0002-7063-7491en_UK
local.rioxx.authorDilcher, Meik|en_UK
local.rioxx.authorSener, Burcin|en_UK
local.rioxx.authorHascelik, Gulsen|en_UK
local.rioxx.authorPinar, Ahmet|en_UK
local.rioxx.authorUs, Durdal|en_UK
local.rioxx.projectInternal Project|University of Stirling|
local.rioxx.filenameCMI 2011.pdfen_UK
Appears in Collections:Aquaculture Journal Articles

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