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Appears in Collections:Aquaculture Journal Articles
Peer Review Status: Refereed
Title: Genetic characterization of Tribec virus and Kemerovo virus, two tick-transmitted human-pathogenic Orbiviruses
Author(s): Dilcher, Meik
Hasib, Lekbira
Lechner, Marcus
Wieseke, Nicolas
Middendorf, Martin
Marz, Manja
Koch, Andrea
Spiegel, Martin
Dobler, Gerhard
Hufert, Frank T
Weidmann, Manfred
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Keywords: Tribec virus
Kemerovo virus
Issue Date: 5-Feb-2012
Date Deposited: 13-Jan-2014
Citation: Dilcher M, Hasib L, Lechner M, Wieseke N, Middendorf M, Marz M, Koch A, Spiegel M, Dobler G, Hufert FT & Weidmann M (2012) Genetic characterization of Tribec virus and Kemerovo virus, two tick-transmitted human-pathogenic Orbiviruses. Virology, 423 (1), pp. 68-76.
Abstract: We determined the complete genome sequences of Tribeč virus (TRBV) and Kemerovo virus (KEMV), two tick-transmitted Orbiviruses that can cause diseases of the central nervous system and that are currently classified into the Great Island virus serogroup. VP2 proteins of TRBV and KEMV show very low sequence similarity to the homologous VP4 protein of tick-transmitted Great Island virus (GIV). The new sequence data support previous serological classification of these Orbiviruses into the Kemerovo serogroup, which is different from the Great Island virus serogroup. Genome segment 9 of TRBV and KEMV encodes several overlapping ORF's in the + 1 reading frame relative to VP6(Hel). A co-phylogenetic analysis indicates a host switch from insect-borne Orbiviruses toward Ixodes species, which is in disagreement with previously published data.
DOI Link: 10.1016/j.virol.2011.11.020
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