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dc.contributor.authorNavarro-Guillen, Carmenen_UK
dc.contributor.authorEngrola, Sofiaen_UK
dc.contributor.authorCastanheira, Filipaen_UK
dc.contributor.authorBandarra, Narcisaen_UK
dc.contributor.authorHachero-Cruzado, Ismaelen_UK
dc.contributor.authorTocher, Douglas Ren_UK
dc.contributor.authorConceicao, Luis E Cen_UK
dc.contributor.authorMorais, Sofiaen_UK
dc.description.abstractLipid nutrition of marine fish larvae has focused on supplying essential fatty acids (EFA) at high levels to meet requirements for survival, growth and development. However, some deleterious effects have been reported suggesting that excessive supply of EFA might result in insufficient supply of energy substrates, particularly in species with lower EFA requirements such as Senegalese sole (Solea senegalensis). This study addressed how the balance between EFA and non-EFA (better energy sources) affects larval performance, body composition and metabolism and retention of DHA, by formulating enrichment emulsions containing two different vegetable oil sources (olive oil or soybean oil) and three DHA levels. DHA positively affected growth and survival, independent of oil source, confirming that for sole post-larvae it is advantageous to base enrichments on vegetable oils supplying higher levels of energy, and supplement these with a DHA-rich oil. In addition, body DHA levels were generally comparable considering the large differences in their dietary supply, suggesting that the previously reported ∆4 fatty acyl desaturase (fad) operates in vivo and that DHA was synthesized at physiologically significant rates through a mechanism involving transcriptional up-regulation of ∆4fad, which was significantly up-regulated in the low DHA treatments. Furthermore, data suggested that DHA biosynthesis may be regulated by an interaction between dietary n - 3 and n - 6 PUFA, as well as by levels of LC-PUFA, and this may, under certain nutritional conditions, lead to DHA production from C18 precursors. The molecular basis of putative fatty acyl ∆5 and ∆6 desaturation activities remains to be fully determined as thorough searches have found only a single (∆4) Fads2-type transcript. Therefore, further studies are required but this might represent a unique activity described within vertebrate fads.en_UK
dc.relationNavarro-Guillen C, Engrola S, Castanheira F, Bandarra N, Hachero-Cruzado I, Tocher DR, Conceicao LEC & Morais S (2014) Effect of varying dietary levels of LC-PUFA and vegetable oil sources on performance and fatty acids of Senegalese sole post larvae: Puzzling results suggest complete biosynthesis pathway from C18 PUFA to DHA. Comparative Biochemistry and Physiology - Part B: Biochemistry and Molecular Biology, 167, pp. 51-58.
dc.rightsPublished in Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology by Elsevier; Elsevier believes that individual authors should be able to distribute their accepted author manuscripts for their personal voluntary needs and interests, e.g. posting to their websites or their institution’s repository, e-mailing to colleagues. The Elsevier Policy is as follows: Authors retain the right to use the accepted author manuscript for personal use, internal institutional use and for permitted scholarly posting provided that these are not for purposes of commercial use or systematic distribution. An "accepted author manuscript" is the author’s version of the manuscript of an article that has been accepted for publication and which may include any author-incorporated changes suggested through the processes of submission processing, peer review, and editor-author communications.en_UK
dc.subjectDiet energy sourceen_UK
dc.subjectEssential fatty acidsen_UK
dc.subjectFatty acyl desaturaseen_UK
dc.subjectPUFA biosynthesisen_UK
dc.subjectSolea senegalensisen_UK
dc.titleEffect of varying dietary levels of LC-PUFA and vegetable oil sources on performance and fatty acids of Senegalese sole post larvae: Puzzling results suggest complete biosynthesis pathway from C18 PUFA to DHAen_UK
dc.typeJournal Articleen_UK
dc.citation.jtitleComparative Biochemistry and Physiology - Part B: Biochemistry and Molecular Biologyen_UK
dc.type.statusAM - Accepted Manuscripten_UK
dc.contributor.affiliationInstituto de Ciencias Marinas de Andaluciaen_UK
dc.contributor.affiliationUniversity of Algarveen_UK
dc.contributor.affiliationUniversity of Algarveen_UK
dc.contributor.affiliationINRB/IPIMAR, Portugalen_UK
dc.contributor.affiliationCentro IFAPA, Spainen_UK
dc.contributor.affiliationInstitute of Aquacultureen_UK
dc.contributor.affiliationUniversity of Algarveen_UK
dc.contributor.affiliationInstitute of Aquacultureen_UK
rioxxterms.apcnot requireden_UK
rioxxterms.typeJournal Article/Reviewen_UK
local.rioxx.authorNavarro-Guillen, Carmen|en_UK
local.rioxx.authorEngrola, Sofia|en_UK
local.rioxx.authorCastanheira, Filipa|en_UK
local.rioxx.authorBandarra, Narcisa|en_UK
local.rioxx.authorHachero-Cruzado, Ismael|en_UK
local.rioxx.authorTocher, Douglas R|0000-0002-8603-9410en_UK
local.rioxx.authorConceicao, Luis E C|en_UK
local.rioxx.authorMorais, Sofia|en_UK
local.rioxx.projectInternal Project|University of Stirling|
local.rioxx.filenameComplete final.pdfen_UK
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